ARHGEF7

ARHGEF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BY1, 1ZSG, 2L3G
Identifiers
Aliases	ARHGEF7, BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB, Rho guanine nucleotide exchange factor 7
External IDs	OMIM: 605477; MGI: 1860493; HomoloGene: 2895; GeneCards: ARHGEF7; OMA:ARHGEF7 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q34 Start 111,114,559 bp End 111,305,737 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A1.1 Start 11,727,721 bp End 11,835,219 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus sural nerve right hemisphere of cerebellum tibial arteries cerebellar vermis skin of thigh skin of hip right coronary artery subcutaneous adipose tissue left coronary artery Top expressed in lobe of cerebellum cerebellar vermis genital tubercle external carotid artery internal carotid artery barrel cortex endocardial cushion dentate gyrus of hippocampal formation granule cell tail of embryo ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity protein kinase binding Cellular component cytoplasm cytosol cell projection focal adhesion ruffle plasma membrane cell junction soma cell cortex neuron projection storage vacuole lamellipodium intracellular anatomical structure Biological process regulation of GTP binding intracellular signal transduction negative regulation of epidermal growth factor receptor signaling pathway positive regulation of lamellipodium morphogenesis Golgi organization ephrin receptor signaling pathway nervous system development focal adhesion assembly positive regulation of substrate adhesion-dependent cell spreading positive regulation of growth hormone secretion hematopoietic progenitor cell differentiation positive regulation of apoptotic process positive regulation of protein binding regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction positive regulation of fibroblast migration signal transduction lamellipodium assembly positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8874 54126 Ensembl ENSG00000102606 ENSMUSG00000031511 UniProt Q14155 Q9ES28 RefSeq (mRNA) NM_001113511 NM_001113512 NM_001113513 NM_003899 NM_145735 NM_001320851 NM_001320852 NM_001320853 NM_001320854 NM_001330597 NM_001330598 NM_001354046 NM_001354047 NM_001354048 NM_001354049 NM_001354050 NM_001354051 NM_001354052 NM_001354053 NM_001354054 NM_001354055 NM_001354056 NM_001354057 NM_001354058 NM_001354059 NM_001354060 NM_001354061 NM_001113517 NM_001113518 NM_017402 NM_001372321 NM_001372322 NM_001372323 NM_001372324 NM_001372325 NM_001372326 RefSeq (protein) NP_001106983 NP_001106984 NP_001106985 NP_001307780 NP_001307781 NP_001307782 NP_001307783 NP_001317526 NP_001317527 NP_003890 NP_663788 NP_001340975 NP_001340976 NP_001340977 NP_001340978 NP_001340979 NP_001340980 NP_001340981 NP_001340982 NP_001340983 NP_001340984 NP_001340985 NP_001340986 NP_001340987 NP_001340988 NP_001340989 NP_001340990 NP_001106985.1 NP_003890.1 NP_001307780.1 NP_001106989 NP_001106990 NP_059098 NP_001359250 NP_001359251 NP_001359252 NP_001359253 NP_001359254 NP_001359255 Location (UCSC) Chr 13: 111.11 – 111.31 Mb Chr 8: 11.73 – 11.84 Mb PubMed search
Wikidata
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Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.

Function

Rho GTPase play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.

Interactions

ARHGEF7 has been shown to interact with:

• Cbl gene,
• GIT1,
• SHANK1
• SHANK2, and
• SHANK3.

Further reading

• Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L (1998). "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors". Mol. Cell. 1 (2): 183–92. doi:10.1016/S1097-2765(00)80019-2. PMID 9659915.
• Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S, Leventhal PS (1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling". J. Cell Biol. 145 (4): 851–63. doi:10.1083/jcb.145.4.851. PMC 2133183. PMID 10330411.
• Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA (1999). "A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins". J. Biol. Chem. 274 (32): 22393–400. doi:10.1074/jbc.274.32.22393. PMID 10428811.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (2000). "The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing". J. Biol. Chem. 275 (29): 22373–80. doi:10.1074/jbc.275.29.22373. PMID 10896954.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ku GM, Yablonski D, Manser E, Lim L, Weiss A (2001). "A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT". EMBO J. 20 (3): 457–65. doi:10.1093/emboj/20.3.457. PMC 133476. PMID 11157752.
• Koh CG, Tan EJ, Manser E, Lim L (2002). "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family". Curr. Biol. 12 (4): 317–21. doi:10.1016/S0960-9822(02)00652-8. PMID 11864573.
• Brown MC, West KA, Turner CE (2002). "Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway". Mol. Biol. Cell. 13 (5): 1550–65. doi:10.1091/mbc.02-02-0015. PMC 111126. PMID 12006652.
• Shin EY, Shin KS, Lee CS, Woo KN, Quan SH, Soung NK, Kim YG, Cha CI, Kim SR, Park D, Bokoch GM, Kim EG (2003). "Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth". J. Biol. Chem. 277 (46): 44417–30. doi:10.1074/jbc.M203754200. PMID 12226077.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet. 12 (2): 155–67. doi:10.1093/hmg/ddg019. PMID 12499396.
• Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Mignone F, Grillo G, Liuni S, Pesole G (2003). "Computational identification of protein coding potential of conserved sequence tags through cross-species evolutionary analysis". Nucleic Acids Res. 31 (15): 4639–45. doi:10.1093/nar/gkg483. PMC 169873. PMID 12888525.
• Yamamoto Y, Fujimoto Y, Arai R, Fujie M, Usami S, Yamada T (2003). "Retrotransposon-mediated restoration of Chlorella telomeres: accumulation of Zepp retrotransposons at termini of newly formed minichromosomes". Nucleic Acids Res. 31 (15): 4646–53. doi:10.1093/nar/gkg490. PMC 169880. PMID 12888526.
• Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA (2003). "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1–3): 119–23. doi:10.1016/S0014-5793(03)00853-6. PMID 12935897.
• Shin EY, Woo KN, Lee CS, Koo SH, Kim YG, Kim WJ, Bae CD, Chang SI, Kim EG (2004). "Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway". J. Biol. Chem. 279 (3): 1994–2004. doi:10.1074/jbc.M307330200. PMID 14557270.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Lim CS, Kim SH, Jung JG, Kim JK, Song WK (2004). "Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion". J. Biol. Chem. 278 (52): 52116–23. doi:10.1074/jbc.M310974200. PMID 14559906.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

• ARHGEF7 Info with links in the Cell Migration Gateway
• Human ARHGEF7 genome location and ARHGEF7 gene details page in the UCSC Genome Browser.
• Human PAK3 genome location and PAK3 gene details page in the UCSC Genome Browser.