ARMET

MANF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KVD, 2KVE, 2W51
Identifiers
Aliases	MANF, ARMET, ARP, arginine-rich, mutated in early-stage tumors, arginine-rich protein, mesencephalic astrocyte-derived neurotrophic factor, mesencephalic astrocyte derived neurotrophic factor
External IDs	OMIM: 601916; MGI: 1922090; HomoloGene: 4383; GeneCards: MANF; OMA:MANF - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	51,389,397 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; beta cell; ; body of pancreas; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; mucosa of transverse colon; ; anterior pituitary; ; left testis; ; right testis; ; pericardium;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	growth factor activity; RNA binding; lipid binding; sulfatide binding;
Cellular component	nucleus; extracellular region; extracellular space; endoplasmic reticulum; cytosol; endoplasmic reticulum lumen; sarcoplasmic reticulum; sarcoplasmic reticulum lumen;
Biological process	response to unfolded protein; platelet degranulation; neuron projection development; dopaminergic neuron differentiation; regulation of signaling receptor activity; regulation of response to endoplasmic reticulum stress; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7873
	74840
	ENSG00000145050
	ENSMUSG00000032575
	P55145
	Q9CXI5
	NM_006010
	NM_029103
	NP_006001
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Arginine-rich, mutated in early-stage tumors (ARMET), arginine-rich protein (ARP), or mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein that in humans is encoded by the MANF housekeeping gene.^[4]^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145050 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW (Jun 2003). "MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons". J Mol Neurosci. 20 (2): 173–88. doi:10.1385/JMN:20:2:173. PMID 12794311.
^ "Entrez Gene: ARMET arginine-rich, mutated in early stage tumors".

External links

Human MANF genome location and MANF gene details page in the UCSC Genome Browser.

References

External links

Further reading