ASH2L

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ASH2L
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ASH2L, ASH2, ASH2L1, ASH2L2, Bre2, ASH2 like histone lysine methyltransferase complex subunit
External IDs MGI: 1344416 HomoloGene: 3436 GeneCards: ASH2L
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ASH2L
Genomic location for ASH2L
Band 8p11.23 Start 38,105,242 bp[1]
End 38,144,076 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001105214
NM_001261832
NM_001282272
NM_004674

NM_001080793
NM_001286207
NM_011791

RefSeq (protein)

NP_001098684
NP_001248761
NP_001269201
NP_004665

NP_001074262
NP_001273136
NP_035921

Location (UCSC) Chr 8: 38.11 – 38.14 Mb Chr 8: 25.82 – 25.85 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene.[5][6]

Interactions[edit]

ASH2L has been shown to interact with MLL.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129691 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031575 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Jul 1999). "Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene". Cytogenet. Cell Genet. 84 (3-4): 167–72. doi:10.1159/000015248. PMID 10393421. 
  6. ^ "Entrez Gene: ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)". 
  7. ^ Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881Freely accessible. PMID 15199122. 

External links[edit]

Further reading[edit]