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Ash2 (absent, small, or homeotic)-like (Drosophila)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ASH2L ; ASH2; ASH2L1; ASH2L2; Bre2
External IDs OMIM604782 MGI1344416 HomoloGene3436 GeneCards: ASH2L Gene
Species Human Mouse
Entrez 9070 23808
Ensembl ENSG00000129691 ENSMUSG00000031575
UniProt Q9UBL3 Q91X20
RefSeq (mRNA) NM_001105214 NM_001080793
RefSeq (protein) NP_001098684 NP_001074262
Location (UCSC) Chr 8:
38.11 – 38.14 Mb
Chr 8:
25.82 – 25.85 Mb
PubMed search [1] [2]

Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene.[1][2]


ASH2L has been shown to interact with MLL.[3]


  1. ^ Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Jul 1999). "Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene". Cytogenet. Cell Genet. 84 (3-4): 167–72. doi:10.1159/000015248. PMID 10393421. 
  2. ^ "Entrez Gene: ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)". 
  3. ^ Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881. PMID 15199122. 

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