ATP11C is an enzyme that in humans is encoded by the ATP11C gene.
Function [ edit ]
ATP11C encodes a member of the Type IV
P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells,  and for the prevention of intrahepatic  cholestasis.
References [ edit ]
^ a b c
GRCh38: Ensembl release 89: ENSG00000101974 - Ensembl, May 2017
"Human PubMed Reference:".
"Mouse PubMed Reference:".
Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi: 10.1038/ni.2012. PMC . 3079768 PMID 21423172.
Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi: 10.1038/ni.2011. PMC . 3272780 PMID 21423173.
Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. doi: 10.1073/pnas.1104631108. PMC . 3093471 PMID 21518881.