ATP11C

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
ATP11C
Identifiers
AliasesATP11C, ATPIG, ATPIQ, ATPase phospholipid transporting 11C, HACXL
External IDsMGI: 1859661 HomoloGene: 27862 GeneCards: ATP11C
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for ATP11C
Genomic location for ATP11C
BandXq27.1Start139,726,346 bp[1]
End139,945,276 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001010986
NM_173694
NM_001353810
NM_001353811
NM_001353812

NM_001001798
NM_001037863

RefSeq (protein)

NP_001010986
NP_775965
NP_001340739
NP_001340740
NP_001340741

NP_001001798
NP_001032952
NP_001345931

Location (UCSC)Chr X: 139.73 – 139.95 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

ATP11C is an enzyme that in humans is encoded by the ATP11C gene.

Function[edit]

ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells,[4][5] and for the prevention of intrahepatic cholestasis.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101974 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ "Mouse PubMed Reference:".
  4. ^ Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC 3079768. PMID 21423172.
  5. ^ Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC 3272780. PMID 21423173.
  6. ^ Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. doi:10.1073/pnas.1104631108. PMC 3093471. PMID 21518881.