ATP12A

ATP12A
Identifiers
Aliases	ATP12A, ATP1AL1, #945, HK, ATPase H+/K+ transporting non-gastric alpha2 subunit, H-K-ATPase
External IDs	OMIM: 182360; MGI: 1926943; HomoloGene: 68197; GeneCards: ATP12A; OMA:ATP12A - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	24,712,472 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,626,007 bp
RNA expression pattern
	Top expressed in
	trachea; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; epithelium of bronchus; ; epithelium of nasopharynx; ; bronchial epithelial cell; ; testicle; ; vulva; ; mucosa of paranasal sinus; ; oral cavity;
	Top expressed in
	left colon; ; seminal vesicula; ; lip; ; cervix; ; skin of external ear; ; skin of abdomen; ; embryo; ; skin of back; ; left lung lobe; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; metal ion binding; ATPase-coupled cation transmembrane transporter activity; hydrolase activity; ATP binding; P-type sodium:potassium-exchanging transporter activity; P-type potassium:proton transporter activity; P-type potassium transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; basolateral plasma membrane; potassium:proton exchanging ATPase complex;
Biological process	sodium ion transport; ion transport; potassium ion transport; potassium ion homeostasis; regulation of pH; establishment or maintenance of transmembrane electrochemical gradient; proton transmembrane transport; cellular sodium ion homeostasis; cellular potassium ion homeostasis; sodium ion export across plasma membrane; potassium ion import across plasma membrane; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	479
	192113
	ENSG00000075673
	ENSMUSG00000022229
	P54707
	Q9Z1W8
	NM_001676; NM_001185085
	NM_138652
	NP_001172014; NP_001667
	NP_619593
	Wikidata
View/Edit Human	View/Edit Mouse

ATPase, H+/K+ transporting, nongastric, alpha polypeptide (also known as ATP12A) is a protein that in humans is encoded by the ATP12A gene.^[5]^[6]^[7]

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075673 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022229 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide".
^ Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
^ Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na⁺, K⁺-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.

Function

References

Further reading