ATP6V1B2

ATP6V1B2
Identifiers
Aliases	ATP6V1B2, ATP6B1B2, ATP6B2, HO57, VATB, VPP3, Vma2, ATPase H+ transporting V1 subunit B2, DOOD, ZLS2
External IDs	OMIM: 606939; MGI: 109618; HomoloGene: 1279; GeneCards: ATP6V1B2; OMA:ATP6V1B2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	20,226,819 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	69,566,363 bp
RNA expression pattern
	Top expressed in
	pons; ; monocyte; ; prefrontal cortex; ; Brodmann area 10; ; orbitofrontal cortex; ; frontal pole; ; dorsolateral prefrontal cortex; ; superior vestibular nucleus; ; Brodmann area 9; ; superior frontal gyrus;
	Top expressed in
	pontine nuclei; ; entorhinal cortex; ; cingulate gyrus; ; medial vestibular nucleus; ; inferior colliculus; ; primary motor cortex; ; medial dorsal nucleus; ; superior colliculus; ; paraventricular nucleus of hypothalamus; ; dorsal tegmental nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	proton-transporting ATPase activity, rotational mechanism; protein binding; proton transmembrane transporter activity; hydrolase activity; ATP binding;
Cellular component	cytoplasm; integral component of membrane; proton-transporting V-type ATPase, V1 domain; cytosol; intracellular membrane-bounded organelle; membrane; melanosome; ruffle; myelin sheath; plasma membrane; microvillus; lysosomal membrane; extracellular exosome; endomembrane system; apical plasma membrane;
Biological process	insulin receptor signaling pathway; transferrin transport; ion transport; ion transmembrane transport; ATP metabolic process; regulation of macroautophagy; phagosome acidification; transport; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	526
	11966
	ENSG00000147416
	ENSMUSG00000006273
	P21281
	P62814
	NM_001693
	NM_007509
	NP_001684
	NP_031535
	Wikidata
View/Edit Human	View/Edit Mouse

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147416 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006273 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bernasconi P, Rausch T, Struve I, Morgan L, Taiz L (Nov 1990). "An mRNA from human brain encodes an isoform of the B subunit of the vacuolar H(+)-ATPase". J Biol Chem. 265 (29): 17428–31. PMID 2145275.
^ Smith AN, Lovering RC, Futai M, Takeda J, Brown D, Karet FE (Oct 2003). "Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes". Mol Cell. 12 (4): 801–3. doi:10.1016/S1097-2765(03)00397-6. PMID 14580332.
^ "Entrez Gene: ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2".

External links

Human ATP6V1B2 genome location and ATP6V1B2 gene details page in the UCSC Genome Browser.

References

External links

Further reading