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ATP6V1F

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ATP6V1F
Identifiers
AliasesATP6V1F, ATP6S14, VATF, Vma7, ATPase H+ transporting V1 subunit F
External IDsOMIM: 607160; MGI: 1913394; HomoloGene: 3119; GeneCards: ATP6V1F; OMA:ATP6V1F - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004231
NM_001198909

NM_025381

RefSeq (protein)

NP_001185838
NP_004222

NP_079657

Location (UCSC)Chr 7: 128.86 – 128.87 MbChr 6: 29.47 – 29.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ATP-synt_F
Identifiers
SymbolATP-synt_F
PfamPF01990
InterProIPR008218
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

V-type proton ATPase subunit F is an enzyme that in humans is encoded by the ATP6V1F gene.[5][6][7]

Template:PBB Summary

Subunit F is a 16 kDa protein that is required for the assembly and activity of V-ATPase, and has a potential role in the differential targeting and regulation of the enzyme for specific organelles. This subunit is not necessary for the rotation of the ATPase V1 rotor, but it does promote catalysis.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128524Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004285Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fujiwara T, Kawai A, Shimizu F, Hirano H, Okuno S, Takeda S, Ozaki K, Shimada Y, Nagata M, Watanabe T, et al. (Mar 1996). "Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit)". DNA Res. 2 (3): 107–11. doi:10.1093/dnares/2.3.107. PMID 8581736.
  6. ^ Peng SB, Crider BP, Tsai SJ, Xie XS, Stone DK (Jun 1996). "Identification of a 14-kDa subunit associated with the catalytic sector of clathrin-coated vesicle H+-ATPase". J Biol Chem. 271 (6): 3324–7. doi:10.1074/jbc.271.6.3324. PMID 8621738.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  7. ^ "Entrez Gene: ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F".
  8. ^ Imamura H, Ikeda C, Yoshida M, Yokoyama K (April 2004). "The F subunit of Thermus thermophilus V1-ATPase promotes ATPase activity but is not necessary for rotation". J. Biol. Chem. 279 (17): 18085–90. doi:10.1074/jbc.M314204200. PMID 14963028.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading

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This article incorporates text from the public domain Pfam and InterPro: IPR008218