The concept of adaptogens was originally created in 1947 to describe a substance that may increase resistance to stress. The term "adaptogenesis" was later applied in the former Soviet Union to describe remedies thought to increase the resistance of organisms to biological stress. Most of the studies conducted on adaptogens were performed in the Soviet Union, Korea, and China before the 1980s, and have been dismissed for various methodological flaws and false concepts. The term is currently not accepted in pharmacological, physiological, or mainstream clinical practices in the European Union.
- "Adaptogen". Dictionary.com. 2012.
- Brekhman, I. I.; Dardymov, I. V. (1969). "New Substances of Plant Origin which Increase Nonspecific Resistance". Annual Review of Pharmacology. 9: 419–430. doi:10.1146/annurev.pa.09.040169.002223. PMID 4892434.
- "Reflection Paper on the Adaptogenic Concept" (PDF). European Medicines Agency, Committee on Herbal Medicinal Products. 8 May 2008. Retrieved 26 October 2020.