Adipose triglyceride lipase

PNPLA2
Identifiers
Aliases	PNPLA2, 1110001C14Rik, ATGL, PEDF-R, TTS-2.2, TTS2, iPLA2zeta, FP17548, patatin like phospholipase domain containing 2
External IDs	OMIM: 609059; MGI: 1914103; HomoloGene: 10687; GeneCards: PNPLA2; OMA:PNPLA2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	825,573 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,040,656 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; subcutaneous adipose tissue; ; left coronary artery; ; gastric mucosa; ; right lung; ; mucosa of transverse colon; ; minor salivary glands; ; body of stomach; ; right coronary artery; ; gastrocnemius muscle;
	Top expressed in
	lactiferous gland; ; brown adipose tissue; ; white adipose tissue; ; muscle of thigh; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; intercostal muscle; ; interventricular septum; ; cardiac muscles; ; myocardium of ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; lipoprotein lipase activity; acylglycerol O-acyltransferase activity; triglyceride lipase activity;
Cellular component	integral component of membrane; cytosol; lipid droplet; plasma membrane; endoplasmic reticulum membrane; cytoplasm; membrane; nucleoplasm; endoplasmic reticulum lumen;
Biological process	lipid catabolic process; lipid storage; metabolism; negative regulation of sequestering of triglyceride; positive regulation of triglyceride catabolic process; acylglycerol acyl-chain remodeling; lipid droplet organization; lipid metabolism; triglyceride catabolic process; lipid homeostasis; post-translational protein modification; cellular lipid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	57104
	66853
	ENSG00000177666
	ENSMUSG00000025509
	Q96AD5
	Q8BJ56
	NM_020376
	NM_001163689; NM_025802
	NP_065109
	NP_001157161; NP_080078
	Wikidata
View/Edit Human	View/Edit Mouse

Adipose triglyceride lipase also known as patatin-like phospholipase domain-containing protein 2 is an enzyme that in humans is encoded by the PNPLA2 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177666 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025509 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
^ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family" (PDF). J Lipid Res. 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: PNPLA2 patatin-like phospholipase domain containing 2".

External links

Human PNPLA2 genome location and PNPLA2 gene details page in the UCSC Genome Browser.

Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Villena JA, Roy S, Sarkadi-Nagy E, et al. (2004). "Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis". J. Biol. Chem. 279 (45): 47066–75. doi:10.1074/jbc.M403855200. PMID 15337759.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Jenkins CM, Mancuso DJ, Yan W, et al. (2005). "Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities". J. Biol. Chem. 279 (47): 48968–75. doi:10.1074/jbc.M407841200. PMID 15364929.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Zimmermann R, Strauss JG, Haemmerle G, et al. (2004). "Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase". Science. 306 (5700): 1383–6. doi:10.1126/science.1100747. PMID 15550674.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Smirnova E, Goldberg EB, Makarova KS, et al. (2006). "ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells". EMBO Rep. 7 (1): 106–13. doi:10.1038/sj.embor.7400559. PMC 1369222. PMID 16239926.
Schoenborn V, Heid IM, Vollmert C, et al. (2006). "The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes". Diabetes. 55 (5): 1270–5. doi:10.2337/db05-1498. PMID 16644682.
Lass A, Zimmermann R, Haemmerle G, et al. (2007). "Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome". Cell Metab. 3 (5): 309–19. doi:10.1016/j.cmet.2006.03.005. PMID 16679289.
Mairal A, Langin D, Arner P, Hoffstedt J (2007). "Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity". Diabetologia. 49 (7): 1629–36. doi:10.1007/s00125-006-0272-x. PMID 16752181.
Notari L, Baladron V, Aroca-Aguilar JD, et al. (2007). "Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor". J. Biol. Chem. 281 (49): 38022–37. doi:10.1074/jbc.M600353200. PMID 17032652.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Fischer J, Lefèvre C, Morava E, et al. (2007). "The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy". Nat. Genet. 39 (1): 28–30. doi:10.1038/ng1951. PMID 17187067.
Rydén M, Jocken J, van Harmelen V, et al. (2007). "Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis". Am. J. Physiol. Endocrinol. Metab. 292 (6): E1847–55. doi:10.1152/ajpendo.00040.2007. PMID 17327373.
Jocken JW, Langin D, Smit E, et al. (2007). "Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state". J. Clin. Endocrinol. Metab. 92 (6): 2292–9. doi:10.1210/jc.2006-1318. PMID 17356053.
Steinberg GR, Kemp BE, Watt MJ (2007). "Adipocyte triglyceride lipase expression in human obesity". Am. J. Physiol. Endocrinol. Metab. 293 (4): E958–64. doi:10.1152/ajpendo.00235.2007. PMID 17609260.
Fischer J, Negre-Salvayre A, Salvayre R (2007). "[Neutral lipid storage diseases and ATGL (adipose triglyceride lipase) and CGI-58/ABHD5 (alpha-beta hydrolase domain-containing 5) deficiency: myopathy, ichthyosis, but no obesity]". Med Sci (Paris). 23 (6–7): 575–8. doi:10.1051/medsci/20072367575. PMID 17631826.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177666 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025509 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8619474-5] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[pmid16799181-6] Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family" (PDF). J Lipid Res. 47 (9): 1940–9. doi:10.1194/jlr.M600185-JLR200. PMID 16799181.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid19029121-7] Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi:10.1194/jlr.R800082-JLR200. PMC 2674697. PMID 19029121.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[entrez-8] "Entrez Gene: PNPLA2 patatin-like phospholipase domain containing 2".

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References

External links

Further reading