Ajit Johnson

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Ajit Johnson
Ajit Johnson Nirmal.jpg
Dr. Nirmal at the Intelligent Systems for Molecular Biology conference in 2015
Chennai, India
Alma mater
Known for
Scientific career
InstitutionsHarvard University, Dana–Farber Cancer Institute

Ajit Johnson Nirmal is a cancer geneticist. He has also campaigned to raise awareness on tech addiction and net neutrality.[1][2]


Born in Vellore, Johnson graduated with a bachelor's degree in biotechnology at Karunya University. Johnson graduated from University College London in 2011 and worked at the Indian Institute of Science. He earned a Doctor of Philosophy in cancer genetics and genomics from the University of Edinburgh[3] and performed his post-doctoral work at Harvard Medical School and Dana Farber Cancer Institute.[4]



Johnson and colleagues developed a cell based gene therapy for haemophilia patients at the National Cancer Centre Singapore.[5][6] Johnson developed ImSig, a network-based computational framework that facilitates the characterization of immune cells within the tumor microenvironment.[7] Johnson's work involves multi-dimensional characterization (genetic, transcriptional, spatial and biophysical attributes) of the tumor ecosystem [8] and understanding the differences in molecular signature of immune cells [9] across tumours.


  1. ^ Cashin, Declan. "These Posters Perfectly Sum Up Twentysomethings' Addiction to the Internet". BuzzFeed.
  2. ^ Bulkley, McKenna. "The Truth About #ThisGeneration". www.huffingtonpost.com.
  3. ^ Nirmal, Ajit Johnson (28 September 2018). "British Library Thesis Collection". University of Edinburgh.{{cite web}}: CS1 maint: url-status (link)
  4. ^ Nirmal, Ajit Johnson. "Harvard Scholar- Ajit Johnson Nirmal".
  5. ^ Sivalingam, Jaichandran; Kenanov, Dimitar; Han, Hao; Nirmal, Ajit Johnson; Ng, Wai Har; Lee, Sze Sing; Masilamani, Jeyakumar; Phan, Toan Thang; Maurer-Stroh, Sebastian; Kon, Oi Lian (1 March 2016). "Multidimensional Genome-wide Analyses Show Accurate FVIII Integration by ZFN in Primary Human Cells". Molecular Therapy. 24 (3): 607–619. doi:10.1038/mt.2015.223. ISSN 1525-0016. PMC 4786920. PMID 26689265.
  6. ^ Lee, Sze Sing; Sivalingam, Jaichandran; Nirmal, Ajit J.; Ng, Wai Har; Kee, Irene; Song, In Chin; Kiong, Chin Yong; Gales, Kristoffer A.; Chua, Frederic; Pena, Edgar M.; Ogden, Bryan E. (1 July 2018). "Durable engraftment of genetically modified FVIII‐secreting autologous bone marrow stromal cells in the intramedullary microenvironment". Journal of Cellular and Molecular Medicine. 22 (7): 3698–3702. doi:10.1111/jcmm.13648. ISSN 1582-1838. PMC 6010829. PMID 29682884.
  7. ^ Nirmal, Ajit J.; Regan, Tim; Shih, Barbara B.; Hume, David A.; Sims, Andrew H.; Freeman, Tom C. (28 September 2018). "Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors". Cancer Immunology Research. 6 (11): 1388–1400. doi:10.1158/2326-6066.CIR-18-0342. ISSN 2326-6066. PMID 30266715.
  8. ^ Nirmal, Ajit Johnson. "Harvard Scholar Page". Harvard University.{{cite web}}: CS1 maint: url-status (link)
  9. ^ Shih, Barbara B; Nirmal, Ajit J; Headon, Denis J; Akbar, Arne N; Mabbott, Neil A; Freeman, Tom C (1 April 2017). "Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders". The Journal of Pathology. 241 (5): 600–613. doi:10.1002/path.4864. ISSN 0022-3417. PMC 5363360. PMID 28008606.

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