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Alanine—oxomalonate transaminase

From Wikipedia, the free encyclopedia
alanine-oxomalonate transaminase
Identifiers
EC no.2.6.1.47
CAS no.37277-96-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an alanine-oxomalonate transaminase (EC 2.6.1.47) is an enzyme that catalyzes the chemical reaction

L-alanine + oxomalonate pyruvate + aminomalonate

Thus, the two substrates of this enzyme are L-alanine and oxomalonate, whereas its two products are pyruvate and aminomalonate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-alanine:oxomalonate aminotransferase. Other names in common use include alanine-oxomalonate aminotransferase, L-alanine-ketomalonate transaminase, and alanine-ketomalonate (mesoxalate) transaminase. It employs one cofactor, pyridoxal phosphate.

References

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  • Nagayama H, Muramatsu M, Shimura K (1958). "Enzymatic formation of aminomalonic acid from ketomalonic acid". Nature. 181 (4606): 417–418. doi:10.1038/181417a0. PMID 13504217.