Amezinium metilsulfate

Amezinium metilsulfate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	C01CA25 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 6-Methoxy-1-phenylpyridazin-1-ium-4-amine; methyl sulfate;
CAS Number	30578-37-1 ;
PubChem CID	71926;
ChemSpider	64937 ;
UNII	03NR868ICX;
KEGG	D01304 ;
ChEMBL	ChEMBL2106667 ;
CompTox Dashboard (EPA)	DTXSID00184657 ;
ECHA InfoCard	100.045.665
Chemical and physical data
Formula	C12H15N3O5S
Molar mass	313.32 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=[N+](N=CC(=C1)N)C2=CC=CC=C2.COS(=O)(=O)[O-];
	InChI InChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4) ; Key:ZEASXVYVFFXULL-UHFFFAOYSA-N ;
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Amezinium metilsulfate (INN, trade name Regulton) is a sympathomimetic drug used for the treatment of low blood pressure. It has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.^[1]^[2]

References

^ Araújo, D; Caramona, MM; Osswald, W (1983). "On the mechanism of action of amezinium methylsulphate on the dog saphenous vein". European Journal of Pharmacology. 90 (2–3): 203–14. doi:10.1016/0014-2999(83)90238-8. PMID 6873182.
^ Lenke, D.; Gries, J.; Kretzschmar, R. (1981). "Pharmacology of amezinium, a novel antihypotensive drug. III. Studies on the mechanism of action". Arzneimittel-Forschung. 31 (9a): 1558–1565. PMID 7197970.

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