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Anjali Kusumbe

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Anjali Kusumbe
Scientific career
InstitutionsWeatherall Institute of Molecular Medicine
WebsiteKusumbe Lab

Anjali Kusumbe is a British-Indian biologist who is the Head of the Tissue and Tumour Microenvironments Group at the Medical Research Council Weatherall Institute of Molecular Medicine at the University of Oxford. She was awarded the Royal Microscopical Society Award for Life Sciences in 2022.

Early life and education

Kusumbe completed her doctorate as a Fellow of the Council of Scientific and Industrial Research in 2012.[1] Her doctoral research considered the contributions of cancer stem cells and endothelial cells to the progression of ovarian cancer.[2] She moved to the Max Planck Institute for Molecular Biomedicine for postdoctoral research,[3] where she studied the heterogeneity of endothelial cells in bone, and uncovered a highly specialised blood vessel type which helped to uncover the relationships between bone vasculature and bone ageing.[2][4]

Research and career

In 2017, Kusumbe received the Medical Research Council Career Development Award, and in 2019 she was awarded a European Research Council Starting Grant.[5] Kusumbe studies the transport networks formed by blood and lymphatic vessels. She is particularly interested in how these vessels evolve over time, and how this impacts the tissue regeneration, immune cells and spread of cancer.[5]

Her work revealed that vascular erosion characterised by the differentiation of pericyte to fibroblast is a primary hallmark of many ageing tissues. This vascular loss with ageing is organ-specific as highly remodelling tissues like the gut and skin retain vasculature with ageing. Further, her work showed that the gap junction protein Gja1 is the driver of endothelial cell ageing in the pancreas, and aged blood vessels cause the loss of beta cell proliferation in ageing islets through alterations in blood vessel-derived secreted factors. Her lab has proactively shared imaging tools with the scientific community and made 3D tissue maps publicly available through freely accessible open resource databases.

Awards and honours

  • 2014 German Society for Cell Biology Werner-Risau Memorial Award[6]
  • 2021 European Calcified Tissue Society Iain T Boyle Memorial Award[7]
  • 2021 Orthopaedic Research Society Alice L. Jee Award[8][failed verification]
  • 2022 Royal Microscopical Society Award for Life Sciences[9]
  • 2022 GOLD Award for efforts to improve sustainability and efficiency from Laboratory Efficiency Assessment Framework[10]
  • 2023 British Society for Cell Biology, Women in Cell Biology Early Career Medal

Selected publications

  • Saravana K Ramasamy; Anjali P Kusumbe; Lin Wang; Ralf H Adams (12 March 2014). "Endothelial Notch activity promotes angiogenesis and osteogenesis in bone". Nature. 507 (7492): 376–380. doi:10.1038/NATURE13146. ISSN 1476-4687. PMC 4943529. PMID 24647000. Wikidata Q37091548.
  • Anjali P Kusumbe; Saravana K Ramasamy; Tomer Itkin; Maarja Andaloussi Mäe; Urs H Langen; Christer Betsholtz; Tsvee Lapidot; Ralf H Adams (13 April 2016). "Age-dependent modulation of vascular niches for haematopoietic stem cells". Nature. 532 (7599): 380–384. doi:10.1038/NATURE17638. ISSN 1476-4687. PMC 5035541. PMID 27074508. Wikidata Q37280872. (erratum)
  • Saravana K Ramasamy; Anjali P Kusumbe; Maria Schiller; et al. (6 December 2016). "Blood flow controls bone vascular function and osteogenesis". Nature Communications. 7: 13601. Bibcode:2016NatCo...713601R. doi:10.1038/NCOMMS13601. ISSN 2041-1723. PMC 5150650. PMID 27922003. Wikidata Q30831553.

References

  1. ^ UCL (2021-10-21). "DoM Seminar: Professor Anjali Kusumbe". UCL Division of Medicine. Retrieved 2022-09-30.
  2. ^ a b "Anjali Kusumbe - Vascular Control of Tissue Ageing and Regeneration". www.mdc-berlin.de. Retrieved 2022-09-30.
  3. ^ "Award for Max Planck Scientist Anjali Kusumbe from Münster". www.mpi-muenster.mpg.de. Retrieved 2022-09-30.
  4. ^ "Newly discovered blood vessel type in bone is responsible for bone-formation". www.mpi-muenster.mpg.de. Retrieved 2022-09-30.
  5. ^ a b "ERC Starting Grant for Dr Anjali Kusumbe — The Kennedy Institute of Rheumatology". www.kennedy.ox.ac.uk. Retrieved 2022-09-30.
  6. ^ "Laureats". The Werner-Risau-Prize. Retrieved 2022-09-30.
  7. ^ "Professor Anjali Kusumbe awarded the ECTS Iain T Boyle Award". The Kennedy Trust for Rheumatology Research. 2021-05-24. Retrieved 2022-09-30.
  8. ^ www.ors.org https://www.ors.org/ors-2022-msb-abstract-submission/. Retrieved 2022-09-30. {{cite web}}: Missing or empty |title= (help)
  9. ^ "Winners of latest RMS Awards revealed!". www.rms.org.uk. Retrieved 2022-09-30.
  10. ^ "Kusumbe Lab | Tissue and Tumor Microenvironments — Radcliffe Department of Medicine". www.rdm.ox.ac.uk. Retrieved 2022-09-30.
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