The Allmusic review by Greg Prato awarded the album 3.5 stars stating "Although death metal and prog metal are usually thought of as two different subgenres of heavy metal, in certain cases, there's really not much differentiating the two. Case in point, Origin, and their 2008 release, Antithesis. Although they are extreme sounding in just about every way imaginable (guttural growls, stop-start riffing, metronome-perfect drumming, etc.), the instrumental prowess of Origin's players is mighty impressive here. But be forewarned -- there's not an ounce of melody detected anywhere (just front to back metallic brutality), as evidenced by such over the top assaults as the album opener, "The Aftermath," as well as "Consuming Misery" and "Wrath of Vishnu," among others. Whether you love it or hate it, most would have to agree that Origin's Antithesis is certainly death metal at its most complex and challenging. ".
According to Kerrang! which gave the album 4 stars, the band "...once again pack in more untrammelled ferocity and sheer sonic destruction then can be good for anyone's health". "The album hurtles by on a torrent of almost inhuman blasting, technical fret mangling and the vomitous vocal of James Lee. While there is always a problem that music that relentless can become a little one-dimensional, the blistering intensity demands your attention from violent start to battered finish", reviewer Dan Slesser writes, picking out "the jaw-dropping" 9.5 minute closing title track as the CD's highlight which "definitely slams the door in the face of all corners".