Aphidicolan-16beta-ol synthase

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Aphidicolan-16beta-ol synthase
Identifiers
EC number 4.2.3.42
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Aphidicolan-16beta-ol synthase (EC 4.2.3.42, PbACS) is an enzyme with systematic name 9alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16beta-ol-forming).[1][2] This enzyme catalyses the following chemical reaction

9alpha-copalyl diphosphate + H2O aphidicolan-16beta-ol + diphosphate

This is a bifunctional enzyme, which also has EC 5.5.1.14 activity.

References[edit]

  1. ^ Oikawa, H.; Toyomasu, T.; Toshima, H.; Ohashi, S.; Kawaide, H.; Kamiya, Y.; Ohtsuka, M.; Shinoda, S.; Mitsuhashi, W.; Sassa, T. (2001). "Cloning and functional expression of cDNA encoding aphidicolan-16 β-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin". J. Am. Chem. Soc. 123: 5154–5155. PMID 11457369. doi:10.1021/ja015747j. 
  2. ^ Toyomasu, T.; Nakaminami, K.; Toshima, H.; Mie, T.; Watanabe, K.; Ito, H.; Matsui, H.; Mitsuhashi, W.; Sassa, T.; Oikawa, H. (2004). "Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α". Biosci. Biotechnol. Biochem. 68: 146–152. PMID 14745177. doi:10.1271/bbb.68.146. 

External links[edit]