Apolipoprotein O

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APOO
Identifiers
Aliases APOO, FAM121B, MIC26, Mic23, My025, Apolipoprotein O
External IDs MGI: 1915566 HomoloGene: 11475 GeneCards: APOO
Gene location (Human)
X chromosome (human)
Chr. X chromosome (human)[1]
X chromosome (human)
Genomic location for APOO
Genomic location for APOO
Band Xp22.11 Start 23,833,353 bp[1]
End 23,907,934 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024122

NM_001199337
NM_001199338
NM_001199339
NM_026673

RefSeq (protein)

NP_077027

NP_001186266
NP_001186267
NP_001186268
NP_080949

Location (UCSC) Chr X: 23.83 – 23.91 Mb Chr X: 94.37 – 94.42 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse
ApoO
Identifiers
Symbol ApoO
Pfam PF09769
InterPro IPR019166

Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.[5]

The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.[5]

Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184831 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079508 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (November 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart". J. Biol. Chem. 281 (47): 36289–302. doi:10.1074/jbc.M510861200. PMID 16956892. 

External links[edit]

Further reading[edit]

This article incorporates text from the public domain Pfam and InterPro IPR019166