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B2B, B to B, or B-to-B may refer to:
- Business-to-business, commerce transactions between businesses, such as between a manufacturer and a wholesaler, or between a wholesaler and a retailer
- Bay to Breakers, an annual footrace in San Francisco, California on the third Sunday of May
- Budapest-Bamako, now the largest amateur rally in the world, the largest rally across the Sahara and an important charity car race in Africa
- BtoB (band), K-pop band
- B2B, a controversial and short lived class in the 1979 Sidecar World Championship
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