BAG5

BAG5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9D, 3A8Y
Identifiers
Aliases	BAG5, BAG-5, BCL2 associated athanogene 5, BAG cochaperone 5, CMD2F
External IDs	OMIM: 603885; MGI: 1917619; HomoloGene: 3584; GeneCards: BAG5; OMA:BAG5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	103,562,657 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,679,691 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; skin of thigh; ; skin of hip; ; endothelial cell; ; caput epididymis; ; gums; ; corpus epididymis; ; gingival epithelium;
	Top expressed in
	seminiferous tubule; ; spermatid; ; saccule; ; otic vesicle; ; spermatocyte; ; otic placode; ; supraoptic nucleus; ; dorsal striatum; ; interventricular septum; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chaperone binding; protein binding; protein kinase binding; ubiquitin protein ligase binding; adenyl-nucleotide exchange factor activity;
Cellular component	cytosol; membrane; mitochondrion; inclusion body; perinuclear region of cytoplasm; nucleus;
Biological process	neuron death; negative regulation of neuron projection development; Golgi organization; regulation of inclusion body assembly; negative regulation of protein ubiquitination; protein folding; negative regulation of ubiquitin-protein transferase activity; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of cellular response to heat; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein refolding; regulation of ubiquitin-protein transferase activity; protein stabilization;
	Sources:Amigo / QuickGO
Orthologs
	9529
	70369
	ENSG00000166170
	ENSMUSG00000049792
	Q9UL15
	Q8CI32
	NM_004873; NM_001015048; NM_001015049
	NM_027404; NM_001324480; NM_001324481; NM_001324482
	NP_001015048; NP_001015049; NP_004864
	NP_001311409; NP_001311410; NP_001311411; NP_081680
	Wikidata
View/Edit Human	View/Edit Mouse

BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166170 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049792 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem. 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (Dec 2004). "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration". Neuron. 44 (6): 931–45. doi:10.1016/j.neuron.2004.11.026. PMID 15603737.
^ "Entrez Gene: BAG5 BCL2-associated athanogene 5".

References

Further reading