In 2008 Lowe made his first grade debut in Round two for the South Sydney Rabbitohs against the Canterbury-Bankstown Bulldogs, a game in which he scored the first try of the match and also of his NRL career. In Round 25 of 2009 he scored a try in the Rabbitohs 41–6 flogging of the St. George Illawarra Dragons.
Lowe is the younger brother of fellow RabbitohJaiman Lowe. He was selected to be the 18th man in the Queensland squad for the third State Of Origin game in 2010. He was a part of the Rabbitohs squad that won the 2014 NRL Premiership, being named on an extended bench for the final., Although Lowe did not understand why he was not selected for the top 17 because he is the 3rd longest serving member of the team, he is just below John Sutton and Issac Luke (who was suspended for the grand final).
On Wednesday 5 August 2015, Ben Lowe announced his retirement from the Rabbitohs. Injuries had forced Lowe to retire, with consideration to life after football for him and his family. Lowe 116 first grade games - all for South Sydney between the years of 2008 and 2015. Stated “Due to injuries I’ve had to make the difficult decision to retire from football immediately. It hasn't been the easiest decision to make but after long conversations with family and loved ones it was the best for my welfare and the best for my family as we head into life after football,”.
He played his last NRL game on Saturday 25 July 2015 where South Sydney beat Newcastle by 46 point in a 52-6 score. Lowe played for only 9 minutes off the bench in jersey number 14.