In 2008 Lowe made his first grade debut in Round two for the South Sydney Rabbitohs against the Canterbury-Bankstown Bulldogs, a game in which he scored the first try of the match and also of his NRL career. In Round 25 of 2009 he scored a try in the Rabbitohs 41–6 flogging of the St. George Illawarra Dragons.
Lowe is the younger brother of fellow RabbitohJaiman Lowe. He was selected to be the 18th man in the Queensland squad for the third State Of Origin game in 2010. He was a part of the Rabbitohs squad that won the 2014 NRL Premiership, being named on an extended bench for the final., Although Lowe did not understand why he was not selected for the top 17 because he is the 3rd longest serving member of the team, he is just below John Sutton and Issac Luke (who was suspended for the grand final)