Btz domain

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PDB 2hyi EBI.jpg
structure of the human exon junction complex with a trapped dead-box helicase bound to rna
Symbol Btz
Pfam PF09405
InterPro IPR018545

In molecular biology, the Btz domain (CASC3/Barentsz eIF4AIII binding domain) is a protein domain found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.[1][2]


  1. ^ Bono F, Ebert J, Lorentzen E, Conti E (August 2006). "The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA". Cell. 126 (4): 713–25. PMID 16923391. doi:10.1016/j.cell.2006.08.006. 
  2. ^ Palacios IM, Gatfield D, St Johnston D, Izaurralde E (February 2004). "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay". Nature. 427 (6976): 753–7. PMID 14973490. doi:10.1038/nature02351. 

This article incorporates text from the public domain Pfam and InterPro IPR018545