C11orf30

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EMSY
Protein C11orf30 PDB 1utu.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EMSY, GL002, C11orf30, BRCA2 interacting transcriptional repressor
External IDs MGI: 1924203 HomoloGene: 32465 GeneCards: EMSY
RNA expression pattern
PBB GE C11orf30 219012 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300942
NM_001300943
NM_001300944
NM_020193

NM_172280

RefSeq (protein)

NP_001287871
NP_001287872
NP_001287873
NP_064578

NP_758484.2
NP_758484

Location (UCSC) Chr 11: 76.44 – 76.55 Mb Chr 7: 98.59 – 98.66 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein EMSY is a protein that in humans is encoded by the C11orf30 gene.[3]

Clinical significance[edit]

C11orf30 has been shown to associate with atopy and susceptibility to poly-sensitisation.[4]

Interactions[edit]

C11orf30 has been shown to interact with ZMYND11,[5] BRCA2[5] and CBX1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: C11orf30 chromosome 11 open reading frame 30". 
  4. ^ Amaral, A. F. S.; Minelli, C.; Guerra, S.; Wjst, M.; Probst-Hensch, N.; Pin, I.; Svanes, C.; Janson, C.; Heinrich, J.; Jarvis, D. L. (March 2015). "The locus C11orf30 increases susceptibility to poly-sensitization". Allergy. 70 (3): 328–333. doi:10.1111/all.12557. PMID 25546184. 
  5. ^ a b c Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845. 

External links[edit]

Further reading[edit]