C2C12 is a mouse myoblast cell line. C2C12 cell line is a subclone produced in Helen Blau's Lab in Stanford of myoblasts that were originally obtained by Yaffe and Saxel at the Weizmann Institute of Science in Israel in 1977 through serial passage of myoblasts cultured from the thigh muscle of C3H mice after a crush injury. These cells are capable of differentiation. C2C12 cells are a useful tool to study the differentiation of myoblasts and osteoblasts, to express various proteins, and to explore mechanistic pathways.
- David Yaffe and Ora Saxel (1977). "Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle.". Nature. 270 (5639): 725–727. doi:10.1038/270725a0. PMID 563524.
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