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Protein-coding gene in the species Homo sapiens
Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12),[ 5] [ 6]
Gene and Transcript [ edit ] In the DNA, C6orf62 is 12,529 base pairs long and is located at 6q22.3.[ 7] chromosome 6 on position 22.3 (6q22.3). The mature mRNA sequence is 2498 base-pairs long with 5 exons and 4 intronic regions that translates a protein that is 229 amino acids long and two predicted isoforms of 160 amino acids and 200 amino acids.[ 8] [ 9]
The main transcript is 229 amino acids long and is encoded from 5 exonic regions. There exists two transcript variants that are 200 amino acids and 160 amino acids long. There is a domain of unknown function (DUF4566) present in all three variants and spans positions 1–226 on the main transcript.[ 10] isoelectric point is at a pH of 9.24.[ 11] [ 6]
Protein Interactions [ edit ] C6orf62 is broadly expressed within the human body, however, its protein abundance is not high.[ 14] gallbladder and testis , but it is not predicted to be expressed in the smooth muscle , lymph nodes , the spleen , ovaries , adipose tissue , and soft tissue .
C6orf62 is highly conserved among vertebrates and has orthologs found in invertebrates.
Orthologs in Select Mammals [ edit ]
Genus
Species
Common Name
Date of divergence (MYA)
RefSeq
AA Length
% Identity
% Similarity
Pongo
abelii
Sumatran Orangutan
15.2
NP_001126883.1
232
99
99
Ictidomys
tridecemlineatus
Ground Squirrel
88
XP_005337081.1
231
99
98
Tupaia
chinensis
Treeshrew
85
XP_006162754.1
267
84
98
Rattus
norvegicus
Brown Rat
88
NP_001017510.1
232
99
98
[ 15]
Orthologs in Select Ray-Finned Fish [ edit ]
Genus
Species
Common Name
Date of divergence (MYA)
RefSeq
AA Length
% Identity
% Similarity
Salmo
salar
Salmon
435
XP_014034327.1
233
82
93
Sinocyclocheilus
rhinoceros
Golden-lined Barbell
435
XP_016388718.1
230
87
94
Hippocampus
comes
Seahorse
435
XP_019729847.1
234
80
91
[ 15]
Orthologs in Select Amphibians [ edit ]
Genus
Species
Common Name
Date of divergence (MYA)
RefSeq
AA Length
% Identity
% Similarity
Nanorana
parkeri
High Himalaya Frog
353
XP_018411819.1
232
95
97
Xenopus
trpocalis
African Clawed Frog
353
NP_001120278.1
232
93
98
[ 15]
Orthologs in Select Reptiles [ edit ]
Genus
Species
Common Name
Date of divergence (MYA)
RefSeq
AA Length
% Identity
% Similarity
Chrysemys
picta belli
Painted Turtle
320
XP_005281462.1
233
97
98
Python
vbivittatus
Burmese Python
320
XP_007521998.1
233
96
99
Chelonia
mydas
Green Sea Turtle
320
XP_007060449.1
231
97
98
Alligator
sinensis
Chinese Alligator
320
XP_006034488.1
232
98
99
[ 15]
Orthologs in Select Birds [ edit ]
Genus
Species
Common Name
Date of divergence (MYA)
RefSeq
AA Length
% Identity
% Similarity
Tauraco
erythrolophus
Red-crested Tauraco
320
XP_009991398.1
232
97
Taeniopygia
guttata
Zebra Finch
320
XP_002194166.1
232
98
Manacus
vitellinus
Gold Marked Manakin
320
XP_017925511.1
241
98
Orthologs in Select Invertebrates [ 15]
Genus
Species
Common Name
Date of divergence (MYA)
RefSeq
AA Length
% Identity
% Similarity
Ciona
intestinalis
Sea Squirt
677
XP_002119736.1
233
38
62
Crassostrea
gigas
Pacific Oyster
758
XP_011438527.1
231
62
80
Hellobdella
robusta
Glossiphoniidae Leech
758
XP_009016977.1
264
35
51
Octopus
bimaculoides
Two-Spot Octopus
758
XP_014780369.1
197
60
79
Saccoglossus
kowalevskii
Acorn Worm
627
XP_002741666.1
230
66
83
[ 15]
^ a b c GRCh38: Ensembl release 89: ENSG00000112308 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019132 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Database, GeneCards Human Gene. "C6orf62 Gene - GeneCards | CF062 Protein | CF062 Antibody" . www.genecards.org . Retrieved 2017-02-21 . ^ a b "Tissue expression of C6orf62 - Summary - The Human Protein Atlas" . www.proteinatlas.org . Retrieved 2017-05-08 .^ Kent, WJ; Sugnet, CW; Furey, TS; Roskin, KM; Pringle, TH; Zahler, AM; Haussler, D (2002). "UCSC Genome Browser" . UCSC Genome Browser . Retrieved 2017-02-20 . ^ "PREDICTED: uncharacterized protein C6orf62 isoform X1 [Homo sapiens] - Protein - NCBI" . www.ncbi.nlm.nih.gov . Retrieved 2017-05-08 .^ "PREDICTED: uncharacterized protein C6orf62 isoform X2 [Homo sapiens] - Protein - NCBI" . www.ncbi.nlm.nih.gov . Retrieved 2017-05-08 .^ "C6orf62 chromosome 6 open reading frame 62 [Homo sapiens (human)] - Gene - NCBI" . www.ncbi.nlm.nih.gov . Retrieved 2017-05-08 .^ Volker, Brendel (2006). "SAPS - SDSC Bio Workbench" . SDSC Biology Workbench . Retrieved 2017-05-01 . [permanent dead link ^ a b Lab, Mike Tyers. "C6orf62 (RP1-30M3.4) Result Summary | BioGRID" . thebiogrid.org . Retrieved 2017-05-08 . ^ "1 binary interaction found for search term C6orf62" . IntAct Molecular Interaction Database . EMBL-EBI. Retrieved 2018-08-25 .^ "C6orf62 protein abundance in PaxDb" . pax-db.org . Retrieved 2017-05-08 .^ a b c d e f "NCBI - Basic Local Alignment Search Tool" . NCBI .
