CBLC

CBLC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OP0, 3VRN, 3VRO, 3VRP, 3VRQ, 3VRR
Identifiers
Aliases	CBLC, CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C
External IDs	OMIM: 608453; MGI: 1931457; HomoloGene: 8108; GeneCards: CBLC; OMA:CBLC - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 44,777,869 bp End 44,800,652 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A3 Start 19,512,806 bp End 19,530,734 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon skin of abdomen skin of leg duodenum right lobe of liver body of pancreas jejunal mucosa rectum olfactory zone of nasal mucosa minor salivary glands Top expressed in duodenum intestinal villus right kidney epithelium of stomach jejunum lip proximal tubule colon esophagus lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding phosphotyrosine residue binding calcium ion binding epidermal growth factor receptor binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity receptor tyrosine kinase binding zinc ion binding protein binding Cellular component plasma membrane membrane raft Biological process negative regulation of epidermal growth factor-activated receptor activity cell surface receptor signaling pathway negative regulation of epidermal growth factor receptor signaling pathway negative regulation of MAP kinase activity protein ubiquitination regulation of signaling ubiquitin-dependent protein catabolic process signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23624 80794 Ensembl ENSG00000142273 ENSMUSG00000040525 UniProt Q9ULV8 Q80XL1 RefSeq (mRNA) NM_001130852 NM_012116 NM_001161844 NM_023224 RefSeq (protein) NP_001124324 NP_036248 NP_001155316 NP_075713 Location (UCSC) Chr 19: 44.78 – 44.8 Mb Chr 7: 19.51 – 19.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]

Interactions

CBLC has been shown to interact with FYN and Epidermal growth factor receptor.

External links

• Human CBLC genome location and CBLC gene details page in the UCSC Genome Browser.

Further reading

• Ollendorff V, Mattei M, Fournier E, et al. (1999). "A third human CBL gene is on chromosome 19". Int. J. Oncol. 13 (6): 1159–61. doi:10.3892/ijo.13.6.1159. PMID 9824625.
• Irby RB, Mao W, Coppola D, et al. (1999). "Activating SRC mutation in a subset of advanced human colon cancers". Nat. Genet. 21 (2): 187–90. doi:10.1038/5971. PMID 9988270. S2CID 27129630.
• Ettenberg SA, Keane MM, Nau MM, et al. (1999). "Cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855–66. doi:10.1038/sj.onc.1202499. PMID 10086340.
• Loreto MP, Berry DM, McGlade CJ (2002). "Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
• Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
• Courbard JR, Fiore F, Adélaïde J, et al. (2003). "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH". J. Biol. Chem. 277 (47): 45267–75. doi:10.1074/jbc.M206460200. PMID 12226085.
• Wong ES, Fong CW, Lim J, et al. (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
• Taher TE, Tjin EP, Beuling EA, et al. (2002). "C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". J. Immunol. 169 (7): 3793–800. doi:10.4049/jimmunol.169.7.3793. PMID 12244174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nau MM, Lipkowitz S (2003). "Comparative genomic organization of the cbl genes". Gene. 308: 103–13. doi:10.1016/S0378-1119(03)00471-2. PMID 12711395.
• Kim M, Tezuka T, Tanaka K, Yamamoto T (2004). "Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation". Oncogene. 23 (9): 1645–55. doi:10.1038/sj.onc.1207298. PMID 14661060. S2CID 24925646.
• Kassenbrock CK, Anderson SM (2004). "Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations". J. Biol. Chem. 279 (27): 28017–27. doi:10.1074/jbc.M404114200. PMID 15117950.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.