CBX2 (gene)

CBX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9U, 3H91, 5EPK
Identifiers
Aliases	CBX2, CDCA6, M33, SRXY5, chromobox 2
External IDs	OMIM: 602770; MGI: 88289; HomoloGene: 7256; GeneCards: CBX2; OMA:CBX2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	79,787,983 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,922,096 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; ganglionic eminence; ; ventricular zone; ; testicle; ; right testis; ; apex of heart; ; left testis; ; sperm; ; stromal cell of endometrium;
	Top expressed in
	gastrula; ; mandibular prominence; ; maxillary prominence; ; secondary oocyte; ; zygote; ; primary oocyte; ; somite; ; genital tubercle; ; tail of embryo; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; methylated histone binding; chromatin binding; protein binding;
Cellular component	heterochromatin; euchromatin; PcG protein complex; PRC1 complex; nucleus; nucleoplasm; chromosome;
Biological process	cell differentiation; development of primary sexual characteristics; sex differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	84733
	12416
	ENSG00000173894
	ENSMUSG00000025577
	Q14781
	P30658
	NM_005189; NM_032647
	NM_007623
	NP_005180; NP_116036
	NP_031649
	Wikidata
View/Edit Human	View/Edit Mouse

Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene.^[5]^[6]^[7] According to a New Scientist article CBX2 controls human sex even more so than X/Y chromosomes.^[8]

Interactions

CBX2 (gene) has been shown to interact with RYBP.^[9] It also interacts with the testis determining factor encoded by the SRY gene on the Y chromosome, as both proteins are necessary components of the male cascade.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173894 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025577 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics. 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071.
^ Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology. 34 (4 Suppl): 10–2, discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID 2477932.
^ "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)".
^ Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist, 2009-04-09. Retrieved on 2009-04-14.
^ García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
Katoh-Fukui Y, Tsuchiya R, Shiroishi T, Nakahara Y, Hashimoto N, Noguchi K, Higashinakagawa T (1998). "Male-to-female sex reversal in M33 mutant mice". Nature. 393 (6686): 688–92. doi:10.1038/31482. PMID 9641679.
Pearce JJ, Singh PB, Gaunt SJ (1992). "The mouse has a Polycomb-like chromobox gene". Development. 114 (4): 921–9. PMID 1352241.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173894 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025577 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7782071-5] Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJ, Fontes M (Jul 1995). "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics. 26 (1): 130–3. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071.

[pmid2477932-6] Chodak GW (Nov 1989). "Early detection and screening for prostatic cancer". Urology. 34 (4 Suppl): 10–2, discussion 46–56. doi:10.1016/0090-4295(89)90228-8. PMID 2477932.

[entrez-7] "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)".

[8] Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist, 2009-04-09. Retrieved on 2009-04-14.

[pmid10369680-9] García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.

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Interactions

References

Further reading