Coiled-coil domain containing 137 is a protein that in humans is encoded by the CCDC137 gene. 
Model organisms [ edit ]
Model organisms have been used in the study of CCDC137 function. A conditional knockout mouse line, called Ccdc137 tm1a(KOMP)Wtsi  was generated as part of the  International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.   
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion.  Twenty five tests were carried out on  mutant mice and two significant abnormalities were observed. No  homozygous mutant embryos were recorded during gestation and, in a separate study, no homozygous animals were observed at weaning. The remaining tests were carried out on adult heterozygous mutant animals, but no further abnormalities were seen. 
References [ edit ]
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ "Entrez Gene: Coiled-coil domain containing 137" . Retrieved . 2011-09-20
^ ". Wellcome Trust Sanger Institute. Salmonella infection data for Ccdc137"
^ ". Wellcome Trust Sanger Institute. Citrobacter infection data for Ccdc137"
^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi: 10.1111/j.1755-3768.2010.4142.x.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium".
^ "Mouse Genome Informatics".
^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi: 10.1038/nature10163. PMC . 3572410 PMID 21677750.
^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018. PMID 17218247.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. doi: 10.1186/gb-2011-12-6-224. PMC . 3218837 PMID 21722353.
External links [ edit ]
Further reading [ edit ]