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CDC42EP1

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CDC42EP1
Identifiers
AliasesCDC42EP1, BORG5, CEP1, MSE55, CDC42 effector protein 1
External IDsOMIM: 606084; MGI: 1929763; HomoloGene: 5128; GeneCards: CDC42EP1; OMA:CDC42EP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152243

NM_027219

RefSeq (protein)

NP_689449

NP_081495

Location (UCSC)Chr 22: 37.56 – 37.57 MbChr 15: 78.73 – 78.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.[5][6][7]

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128283Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049521Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bahou WF, Campbell AD, Wicha MS (Aug 1992). "cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression". J Biol Chem. 267 (20): 13986–92. doi:10.1016/S0021-9258(19)49667-1. PMID 1629197.
  6. ^ Burbelo PD, Snow DM, Bahou W, Spiegel S (Sep 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts". Proc Natl Acad Sci U S A. 96 (16): 9083–8. Bibcode:1999PNAS...96.9083B. doi:10.1073/pnas.96.16.9083. PMC 17736. PMID 10430899.
  7. ^ a b "Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1".
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Further reading

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