CDCA7

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CDCA7
Identifiers
AliasesCDCA7, JPO1, ICF3, cell division cycle associated 7
External IDsMGI: 1914203 HomoloGene: 49970 GeneCards: CDCA7
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CDCA7
Genomic location for CDCA7
Band2q31.1Start173,354,820 bp[1]
End173,368,997 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031942
NM_145810

NM_025866

RefSeq (protein)

NP_114148
NP_665809

NP_080142

Location (UCSC)Chr 2: 173.35 – 173.37 MbChr 2: 72.48 – 72.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene.[5][6][7]

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144354 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055612 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". J Biol Chem. 276 (51): 48276–84. doi:10.1074/jbc.M107357200. PMID 11598121.
  6. ^ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  7. ^ a b "Entrez Gene: CDCA7 cell division cycle associated 7".

External links[edit]

Further reading[edit]