CHD1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CHD1
Protein CHD1 PDB 2b2t.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CHD1
External IDs MGI: 88393 HomoloGene: 68174 GeneCards: CHD1
RNA expression pattern
PBB GE CHD1 204258 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270

NM_007690

RefSeq (protein)

NP_001261

NP_031716.2
NP_031716

Location (UCSC) Chr 5: 98.85 – 98.93 Mb Chr 17: 15.7 – 17.39 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Chromodomain-helicase-DNA-binding protein 1 is an enzyme that in humans is encoded by the CHD1 gene.[3][4][5]

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.[5]

Interactions[edit]

CHD1 has been shown to interact with Nuclear receptor co-repressor 1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Delmas V, Stokes DG, Perry RP (Apr 1993). "A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain". Proc Natl Acad Sci U S A. 90 (6): 2414–8. doi:10.1073/pnas.90.6.2414. PMC 46097Freely accessible. PMID 8460153. 
  4. ^ Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS (Nov 1997). "Characterization of the CHD family of proteins". Proc Natl Acad Sci U S A. 94 (21): 11472–7. doi:10.1073/pnas.94.21.11472. PMC 23509Freely accessible. PMID 9326634. 
  5. ^ a b "Entrez Gene: CHD1 chromodomain helicase DNA binding protein 1". 
  6. ^ Tai, Helen H; Geisterfer Margit; Bell John C; Moniwa Mariko; Davie James R; Boucher Lorrie; McBurney Michael W (Aug 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. United States. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. ISSN 0006-291X. PMID 12890497. 

External links[edit]

Further reading[edit]