CLDN2

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CLDN2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CLDN2
External IDs MGI: 1276110 HomoloGene: 9621 GeneCards: CLDN2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020384
NM_001171092
NM_001171095

NM_016675

RefSeq (protein)

NP_001164563
NP_001164566
NP_065117

NP_057884.1
NP_057884

Location (UCSC) Chr X: 106.9 – 106.93 Mb Chr X: 139.8 – 139.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene.[3][4] It belongs to the group of claudins.

Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM][4]

Function[edit]

Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule.[5] Mice that are deficient in claudin-2 have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.[6] Furthermore, claudin-2 has been shown to form paracellular channels for water.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167Freely accessible. PMID 9892664. 
  4. ^ a b "Entrez Gene: CLDN2 claudin 2". 
  5. ^ Muto, S.; Hata, M.; Taniguchi, J.; Tsuruoka, S.; Moriwaki, K.; Saitou, M.; Furuse, K.; Sasaki, H.; Fujimura, A.; Imai, M.; Kusano, E.; Tsukita, S.; Furuse, M. (2010). "Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules". Proceedings of the National Academy of Sciences. 107 (17): 8011–8016. doi:10.1073/pnas.0912901107. PMC 2867900Freely accessible. PMID 20385797. 
  6. ^ Amasheh, S; Meiri, N; Gitter, A. H.; Schöneberg, T; Mankertz, J; Schulzke, J. D.; Fromm, M (2002). "Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells". Journal of Cell Science. 115 (Pt 24): 4969–76. doi:10.1242/jcs.00165. PMID 12432083. 
  7. ^ Rosenthal, R.; Milatz, S.; Krug, S. M.; Oelrich, B.; Schulzke, J. -D.; Amasheh, S.; Gunzel, D.; Fromm, M. (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science. 123 (11): 1913–1921. doi:10.1242/jcs.060665. PMID 20460438. 

External links[edit]

Further reading[edit]