CLDN2

CLDN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YYX
Identifiers
Aliases	CLDN2, claudin 2, OAZON
External IDs	OMIM: 300520; MGI: 1276110; HomoloGene: 9621; GeneCards: CLDN2; OMA:CLDN2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	106,930,861 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	138,712,135 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; gallbladder; ; islet of Langerhans; ; kidney; ; right lobe of liver; ; seminal vesicula; ; renal cortex; ; renal medulla; ; duodenum; ; caput epididymis;
	Top expressed in
	kidney; ; proximal tubule; ; crypt of lieberkuhn of small intestine; ; left colon; ; yolk sac; ; left lobe of liver; ; duodenum; ; ciliary body; ; ileum; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding; structural molecule activity;
Cellular component	cell junction; integral component of membrane; bicellular tight junction; plasma membrane; membrane;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	9075
	12738
	ENSG00000165376
	ENSMUSG00000047230
	P57739
	O88552
	NM_020384; NM_001171092; NM_001171095
	NM_016675
	NP_001164563; NP_001164566; NP_065117
	NP_057884
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene.^[5]^[6] It belongs to the group of claudins.

Template:PBB Summary

Function

Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule.^[7] Mice that are deficient in claudin-2 have reduced reabsorption of Na⁺ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.^[8] Furthermore, claudin-2 has been shown to form paracellular channels for water.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047230 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
^ "Entrez Gene: CLDN2 claudin 2".
^ Muto, S.; Hata, M.; Taniguchi, J.; Tsuruoka, S.; Moriwaki, K.; Saitou, M.; Furuse, K.; Sasaki, H.; Fujimura, A.; Imai, M.; Kusano, E.; Tsukita, S.; Furuse, M. (2010). "Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules". Proceedings of the National Academy of Sciences. 107 (17): 8011–8016. doi:10.1073/pnas.0912901107. PMC 2867900. PMID 20385797.
^ Amasheh, S; Meiri, N; Gitter, A. H.; Schöneberg, T; Mankertz, J; Schulzke, J. D.; Fromm, M (2002). "Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells". Journal of Cell Science. 115 (Pt 24): 4969–76. doi:10.1242/jcs.00165. PMID 12432083.
^ Rosenthal, R.; Milatz, S.; Krug, S. M.; Oelrich, B.; Schulzke, J. -D.; Amasheh, S.; Gunzel, D.; Fromm, M. (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science. 123 (11): 1913–1921. doi:10.1242/jcs.060665. PMID 20460438.

Function

References

Further reading