CLEC2D

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CLEC2D
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CLEC2D, CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDs HomoloGene: 137257 GeneCards: CLEC2D
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001004419
NP_001184246
NP_001184247
NP_001184248
NP_037401

n/a

Location (UCSC) Chr 12: 9.66 – 9.7 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.[2]

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.[2] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.

References[edit]

Further reading[edit]