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COG2

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COG2
Identifiers
AliasesCOG2, LDLC, component of oligomeric golgi complex 2, CDG2Q
External IDsOMIM: 606974; MGI: 1923582; HomoloGene: 7206; GeneCards: COG2; OMA:COG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007357
NM_001145036

NM_029746

RefSeq (protein)

NP_001138508
NP_031383

NP_084022

Location (UCSC)Chr 1: 230.64 – 230.69 MbChr 8: 125.25 – 125.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.[5][6]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).[6]

Interactions

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COG2 has been shown to interact with COG4[7] and COG3.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135775Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031979Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Podos SD, Reddy P, Ashkenas J, Krieger M (Dec 1994). "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function". J Cell Biol. 127 (3): 679–91. doi:10.1083/jcb.127.3.679. PMC 2120235. PMID 7962052.
  6. ^ a b "Entrez Gene: COG2 component of oligomeric golgi complex 2".
  7. ^ Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
  8. ^ Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.
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Further reading

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