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COP9 signalosome complex subunit 3

From Wikipedia, the free encyclopedia

COPS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOPS3, CSN3, SGN3, COP9 signalosome subunit 3
External IDsOMIM: 604665; MGI: 1349409; HomoloGene: 2710; GeneCards: COPS3; OMA:COPS3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011991

RefSeq (protein)

NP_036121

Location (UCSC)Chr 17: 17.25 – 17.28 MbChr 11: 59.82 – 59.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.[5][6][7] It encodes a subunit of the COP9 signalosome.

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141030Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019373Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.
  6. ^ Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics. 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.
  7. ^ a b "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".
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Further reading

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