CPSF4

CPSF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9N, 2RHK
Identifiers
Aliases	CPSF4, CPSF30, NAR, NEB1, NEB-1, cleavage and polyadenylation specific factor 4
External IDs	OMIM: 603052; MGI: 1861602; HomoloGene: 38216; GeneCards: CPSF4; OMA:CPSF4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	99,457,373 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	145,118,851 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right hemisphere of cerebellum; ; gastric mucosa; ; right frontal lobe; ; left testis; ; right testis; ; tibial nerve; ; endothelial cell; ; body of pancreas; ; ectocervix;
	Top expressed in
	epiblast; ; cumulus cell; ; yolk sac; ; internal carotid artery; ; external carotid artery; ; mandibular prominence; ; maxillary prominence; ; somite; ; spermatocyte; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; zinc ion binding; protein binding; metal ion binding; endoribonuclease activity; RNA binding;
Cellular component	mRNA cleavage and polyadenylation specificity factor complex; nucleus; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	mRNA processing; modification by virus of host mRNA processing; viral process; tRNA splicing, via endonucleolytic cleavage and ligation; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA polyadenylation; mRNA export from nucleus; mRNA 3'-end processing; RNA phosphodiester bond hydrolysis, endonucleolytic; pre-mRNA cleavage required for polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	10898
	54188
	ENSG00000160917
	ENSMUSG00000029625
	O95639
	Q8BQZ5
	NM_001081559; NM_006693; NM_001318160; NM_001318161; NM_001318162
	NM_001291248; NM_001291249; NM_178576; NM_001374716
	NP_001075028; NP_001305089; NP_001305090; NP_001305091; NP_006684
	NP_001278177; NP_001278178; NP_848671; NP_001361645
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 4 is a protein that in humans is encoded by the CPSF4 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160917 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029625 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nemeroff ME, Barabino SM, Li Y, Keller W, Krug RM (Jul 1998). "Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs". Mol Cell. 1 (7): 991–1000. doi:10.1016/S1097-2765(00)80099-4. PMID 9651582.
^ Barabino SM, Hubner W, Jenny A, Minvielle-Sebastia L, Keller W (Aug 1997). "The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins". Genes Dev. 11 (13): 1703–16. doi:10.1101/gad.11.13.1703. PMID 9224719.
^ "Entrez Gene: CPSF4 cleavage and polyadenylation specific factor 4, 30kDa".

References

Further reading