CTP synthase 1

CTPS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VO1
Identifiers
Aliases	CTPS1, CTPS, IMD24, CTP synthase 1, GATD5
External IDs	OMIM: 123860; MGI: 1858304; HomoloGene: 20446; GeneCards: CTPS1; OMA:CTPS1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 40,979,335 bp End 41,012,565 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.1|4 56.52 cM Start 120,397,065 bp End 120,427,473 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland ascending aorta left uterine tube right coronary artery left coronary artery gonad body of uterus popliteal artery tibial arteries muscle layer of sigmoid colon Top expressed in hair follicle primitive streak primary oocyte superior cervical ganglion mandibular prominence somite maxillary prominence endothelial cell of lymphatic vessel endocardial cushion zygote More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ligase activity ATP binding CTP synthase activity identical protein binding Cellular component cytosol membrane cytoplasm cytoophidium Biological process T cell proliferation B cell proliferation nucleobase-containing small molecule interconversion glutamine metabolic process nucleobase-containing compound metabolic process 'de novo' CTP biosynthetic process pyrimidine nucleotide biosynthetic process immune system process CTP biosynthetic process pyrimidine nucleobase biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1503 51797 Ensembl ENSG00000171793 ENSMUSG00000028633 UniProt P17812 P70698 RefSeq (mRNA) NM_001301237 NM_001905 NM_016748 NM_001355491 RefSeq (protein) NP_001288166 NP_001896 NP_058028 NP_001342420 Location (UCSC) Chr 1: 40.98 – 41.01 Mb Chr 4: 120.4 – 120.43 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CTP synthase 1 is an enzyme that in human s is encoded by the CTPS gene.

Function

The catalytic conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP) is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. This enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis.

Further reading

• Thomas PE, Lamb BJ, Chu EH (1988). "Purification of cytidine-triphosphate synthetase from rat liver, and demonstration of monomer, dimer and tetramer". Biochim. Biophys. Acta. 953 (3): 334–44. doi:10.1016/0167-4838(88)90042-8. PMID 3355843.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Verschuur AC, Van Gennip AH, Muller EJ, et al. (1999). "Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells". Biol. Chem. 380 (1): 41–6. doi:10.1515/BC.1999.005. PMID 10064135.
• Yamauchi M, Yamauchi N, Meuth M (1990). "Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes". EMBO J. 9 (7): 2095–9. PMC 551928. PMID 2113467.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Higgins MJ, Loiselle D, Haystead TA, Graves LM (2008). "Human cytidine triphosphate synthetase 1 interacting proteins". Nucleosides Nucleotides Nucleic Acids. 27 (6): 850–7. doi:10.1080/15257770802146502. PMID 18600551.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Higgins MJ, Graves PR, Graves LM (2007). "Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3". J. Biol. Chem. 282 (40): 29493–503. doi:10.1074/jbc.M703948200. PMID 17681942.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Takahashi E, Yamauchi M, Tsuji H, et al. (1991). "Chromosome mapping of the human cytidine-5'-triphosphate synthetase (CTPS) gene to band 1p34.1-p34.3 by fluorescence in situ hybridization". Hum. Genet. 88 (1): 119–21. doi:10.1007/BF00204942. PMID 1959918.
• Whelan J, Phear G, Yamauchi M, Meuth M (1993). "Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells". Nat. Genet. 3 (4): 317–22. doi:10.1038/ng0493-317. PMID 7981751.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2005). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Han GS, Sreenivas A, Choi MG, et al. (2005). "Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A". J. Biol. Chem. 280 (46): 38328–36. doi:10.1074/jbc.M509622200. PMC 1400552. PMID 16179339.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Chang YF, Martin SS, Baldwin EP, Carman GM (2007). "Phosphorylation of Human CTP Synthetase 1 by Protein Kinase C IDENTIFICATION OF Ser462 AND Thr455 AS MAJOR SITES OF PHOSPHORYLATION". J. Biol. Chem. 282 (24): 17613–22. doi:10.1074/jbc.M702799200. PMC 2081159. PMID 17463002.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.