CUL3

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CUL3
Protein CUL3 PDB 1iuy.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CUL3, CUL-3, PHA2E, cullin 3
External IDs MGI: 1347360 HomoloGene: 2661 GeneCards: CUL3
RNA expression pattern
PBB GE CUL3 201372 s at fs.png

PBB GE CUL3 201371 s at fs.png

PBB GE CUL3 201370 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001257197
NM_001257198
NM_003590

NM_016716
NM_001313728

RefSeq (protein)

NP_001244126
NP_001244127
NP_003581

NP_001300657.1
NP_057925.1
NP_001300657
NP_057925

Location (UCSC) Chr 2: 224.47 – 224.59 Mb Chr 1: 80.26 – 80.34 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cullin-3 is a protein that in humans is encoded by the CUL3 gene.[3][4][5]

Interactions[edit]

CUL3 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Jun 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378. 
  4. ^ Wimuttisuk W, Singer JD (Mar 2007). "The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer". Molecular Biology of the Cell. 18 (3): 899–909. doi:10.1091/mbc.E06-06-0542. PMC 1805106Freely accessible. PMID 17192413. 
  5. ^ "Entrez Gene: CUL3 cullin 3". 
  6. ^ Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". The Journal of Biological Chemistry. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982. 
  7. ^ Singer JD, Gurian-West M, Clurman B, Roberts JM (Sep 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes & Development. 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. PMC 317026Freely accessible. PMID 10500095. 
  8. ^ Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry. 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271Freely accessible. PMID 18826954. 
  9. ^ Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD (Aug 2008). "Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction". Toxicology and Applied Pharmacology. 230 (3): 383–9. doi:10.1016/j.taap.2008.03.003. PMC 2610481Freely accessible. PMID 18417180. 
  10. ^ Rachakonda G, Xiong Y, Sekhar KR, Stamer SL, Liebler DC, Freeman ML (Mar 2008). "Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3". Chemical Research in Toxicology. 21 (3): 705–10. doi:10.1021/tx700302s. PMID 18251510. 
  11. ^ Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (Apr 2008). "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase". The Journal of Biological Chemistry. 283 (17): 11083–96. doi:10.1074/jbc.M708473200. PMC 2431063Freely accessible. PMID 18303015. 

Further reading[edit]