CUL3

CUL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MYL, 2MYM, 4AP2, 4APF, 4EOZ, 4HXI
Identifiers
Aliases	CUL3, CUL-3, PHA2E, cullin 3, NEDAUS
External IDs	OMIM: 603136; MGI: 1347360; HomoloGene: 2661; GeneCards: CUL3; OMA:CUL3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q36.2 Start 224,470,150 bp End 224,585,397 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C5 Start 80,242,640 bp End 80,318,197 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis amniotic fluid epithelium of nasopharynx glutes Achilles tendon parotid gland oral cavity palpebral conjunctiva Top expressed in spermatid spermatocyte seminiferous tubule triceps brachii muscle tail of embryo extensor digitorum longus muscle muscle of thigh quadriceps femoris muscle gastrocnemius muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function POZ domain binding protein homodimerization activity ubiquitin protein ligase activity ubiquitin-protein transferase activity protein binding protein heterodimerization activity ubiquitin protein ligase binding cyclin binding Notch binding Cellular component cytoplasm cullin-RING ubiquitin ligase complex cytosol Golgi apparatus membrane Cul3-RING ubiquitin ligase complex nucleoplasm polar microtubule extracellular exosome nucleus Golgi membrane cilium SCF ubiquitin ligase complex motile cilium sperm flagellum cell projection Biological process embryonic cleavage regulation of transcription by RNA polymerase II G1 phase negative regulation of Rho protein signal transduction protein polyubiquitination in utero embryonic development negative regulation of transcription by RNA polymerase II Wnt signaling pathway protein monoubiquitination stress fiber assembly MAPK cascade positive regulation of cytokinesis intrinsic apoptotic signaling pathway endoplasmic reticulum to Golgi vesicle-mediated transport positive regulation of mitotic metaphase/anaphase transition COPII vesicle coating fibroblast apoptotic process cell projection organization gastrulation stem cell division protein ubiquitination cell morphogenesis positive regulation of cell population proliferation mitotic cell cycle integrin-mediated signaling pathway mitotic metaphase plate congression cell migration negative regulation of canonical Wnt signaling pathway vesicle-mediated transport liver morphogenesis proteasome-mediated ubiquitin-dependent protein catabolic process trophectodermal cellular morphogenesis ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process nuclear protein quality control by the ubiquitin-proteasome system post-translational protein modification transport G1/S transition of mitotic cell cycle SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination protein destabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8452 26554 Ensembl ENSG00000036257 ENSMUSG00000004364 UniProt Q13618 Q9JLV5 RefSeq (mRNA) NM_001257197 NM_001257198 NM_003590 NM_016716 NM_001313728 RefSeq (protein) NP_001244126 NP_001244127 NP_003581 NP_001300657 NP_057925 Location (UCSC) Chr 2: 224.47 – 224.59 Mb Chr 1: 80.24 – 80.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cullin-3 is a protein that in humans is encoded by the CUL3 gene.

Interactions

CUL3 has been shown to interact with:

• CAND1,
• Cyclin E1,
• DCUN1D1,
• KEAP1, and
• KLHL12.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Michel JJ, Xiong Y (Jun 1998). "Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A". Cell Growth & Differentiation. 9 (6): 435–49. PMID 9663463.
• Du M, Sansores-Garcia L, Zu Z, Wu KK (Sep 1998). "Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family". The Journal of Biological Chemistry. 273 (38): 24289–92. doi:10.1074/jbc.273.38.24289. PMID 9733711.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Ohta T, Michel JJ, Schottelius AJ, Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Molecular Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407.
• Singer JD, Gurian-West M, Clurman B, Roberts JM (Sep 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes & Development. 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. PMC 317026. PMID 10500095.
• Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, Kato S, Tanaka K (Nov 1999). "Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829–34. doi:10.1038/sj.onc.1203093. PMID 10597293.
• Maeda I, Ohta T, Koizumi H, Fukuda M (Apr 2001). "In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3". FEBS Letters. 494 (3): 181–5. doi:10.1016/S0014-5793(01)02343-2. PMID 11311237.
• Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (May 2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
• Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". The Journal of Biological Chemistry. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M (Aug 2004). "Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2". Molecular and Cellular Biology. 24 (16): 7130–9. doi:10.1128/MCB.24.16.7130-7139.2004. PMC 479737. PMID 15282312.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Furukawa M, Xiong Y (Jan 2005). "BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase". Molecular and Cellular Biology. 25 (1): 162–71. doi:10.1128/MCB.25.1.162-171.2005. PMC 538799. PMID 15601839.
• Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase". Proceedings of the National Academy of Sciences of the United States of America. 102 (21): 7635–40. doi:10.1073/pnas.0408918102. PMC 1140410. PMID 15897469.
• Lu L, Zhou ZM, Huang XY, Xu M, Yin LL, Wang H, Xu ZY, Sha JH (Jun 2005). "Identification and characterization of cul-3b, a novel hominine CUL-3 transcript variant". Asian Journal of Andrology. 7 (2): 205–11. doi:10.1111/j.1745-7262.2005.00024.x. PMID 15897978.