CYB5R1

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CYB5R1
Identifiers
Aliases CYB5R1, B5R.1, B5R1, B5R2, NQO3A2, humb5R2, cytochrome b5 reductase 1
External IDs MGI: 1919267 HomoloGene: 96059 GeneCards: CYB5R1
RNA expression pattern
PBB GE CYB5R1 202263 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016243

NM_028057

RefSeq (protein)

NP_057327

NP_082333.1
NP_082333

Location (UCSC) Chr 1: 202.96 – 202.97 Mb Chr 1: 134.41 – 134.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

NADH-cytochrome b5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene.[3][4][5]

Structure[edit]

The CYB5R1 gene is located on the 1st chromosome, with its specific location being 1q32.1. The gene contains 9 exons.[5] CYB5R1 encodes a 34.1 kDa protein that is composed of 305 amino acids; 56 peptides have been observed through mass spectrometry data.[6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697Freely accessible. PMID 12975309. 
  4. ^ Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Dec 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14742–7. doi:10.1073/pnas.96.26.14742. PMC 24718Freely accessible. PMID 10611283. 
  5. ^ a b "Entrez Gene: CYB5R1 cytochrome b5 reductase 1". 
  6. ^ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475Freely accessible. PMID 23965338. 
  7. ^ "NADH-cytochrome b5 reductase 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). 

Further reading[edit]

  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Qian W, Sun YL, Wang YH, Zhuang JH, Xie Y, Huang ZX (Oct 1998). "The influence of mutation at Glu44 and Glu56 of cytochrome b5 on the protein's stabilization and interaction between cytochrome c and cytochrome b5". Biochemistry. 37 (40): 14137–50. doi:10.1021/bi9805036. PMID 9760250. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.