From Wikipedia, the free encyclopedia
Jump to: navigation, search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CYFIP1, P140SRA-1, SHYC, SRA-1, SRA1, cytoplasmic FMR1 interacting protein 1
External IDs MGI: 1338801 HomoloGene: 22628 GeneCards: CYFIP1
RNA expression pattern
PBB GE CYFIP1 208923 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 15: 22.87 – 22.98 Mb Chr 7: 55.84 – 55.93 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Cytoplasmic FMR1-interacting protein 1 is a protein that in humans is encoded by the CYFIP1 gene.[3][4]


CYFIP1 has been shown to interact with FMR1,[3] to the exclusion of FXR1 and FXR2.[3] It also forms part of the WAVE regulatory complex (WRC),[5] and based on the crystal structure of the WRC it is believed CYFIP1 provides the binding site for the complex to Rac1.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proc Natl Acad Sci U S A. 98 (15): 8844–9. doi:10.1073/pnas.151231598. PMC 37523Freely accessible. PMID 11438699. 
  4. ^ "Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1". 
  5. ^ Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK (25 Nov 2010). "Structure and control of the actin regulatory WAVE complex". Nature. 468 (7323): 533–8. doi:10.1038/nature09623. PMC 3085272Freely accessible. PMID 21107423. 
  6. ^ Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ (30 Aug 2011). "WAVE regulatory complex activation by cooperating GTPases Arf and Rac1". Proc Natl Acad Sci U S A. 108 (35): 14449–54. doi:10.1073/pnas.1107666108. PMC 3167530Freely accessible. PMID 21844371. 

External links[edit]

Further reading[edit]