Cytokine-like protein 1

CYTL1
Identifiers
Aliases	CYTL1, C17, C4orf4, cytokine like 1
External IDs	OMIM: 607930; MGI: 2684993; HomoloGene: 10254; GeneCards: CYTL1; OMA:CYTL1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	5,019,458 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	37,897,164 bp
RNA expression pattern
	Top expressed in
	tibia; ; trachea; ; ascending aorta; ; Descending thoracic aorta; ; cartilage tissue; ; trabecular bone; ; canal of the cervix; ; popliteal artery; ; tibial arteries; ; ectocervix;
	Top expressed in
	skin of external ear; ; intercostal muscle; ; interventricular septum; ; ankle; ; basilar part of occipital bone; ; aorta; ; laryngeal cartilages; ; right lung lobe; ; stria vascularis; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	inner ear development; chondroitin sulfate proteoglycan biosynthetic process; positive regulation of DNA-binding transcription factor activity; cartilage homeostasis; chondrocyte differentiation; signal transduction; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	54360
	231162
	ENSG00000170891
	ENSMUSG00000062329
	Q9NRR1
	A1E5L0
	NM_018659
	NM_001081106
	NP_061129
	NP_001074575
	Wikidata
View/Edit Human	View/Edit Mouse

Cytokine-like 1 is a protein that in humans is encoded by the CYTL1 gene. ^[5]

Function

C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker[PubMed 10857752]). Functionally, C17 was identified as a secretory protein expressed in CD34+ haemopoietic cells [PMID 10857752]. CYTL1 seems to regulate chondrogenesis and is required for the maintenance of cartilage homeostasis and might, additionally, work as a regulatory factor in embryo implantation in the stage of early pregnancy.^[6]

This family of proteins, C17, is found in vertebrates. Proteins have two conserved sequence motifs: PPTCYSR and DDC.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170891 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062329 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Cytokine-like 1". Retrieved 2014-02-01.
^ Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation" PLoS ONE 11(1): e0147424. doi:10.1371/journal.pone.0147424

Deng, X; Zhao, H. S.; Peng, Z; Deng, W. W.; Li, N; Guo, S; Shi, T. P. (2011). "Study on the mechanism of C17orf62 induced cell death". Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 43 (2): 168–72. PMID 21503106.
Tomczak, A; Pisabarro, M. T. (2011). "Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model". Proteins: Structure, Function, and Bioinformatics. 79 (4): 1277–92. doi:10.1002/prot.22963. PMID 21322034.
Chao, C; Joyce-Shaikh, B; Grein, J; Moshrefi, M; Raoufi, F; Laface, D. M.; McClanahan, T. K.; Bourne, P. A.; Pierce, R. H.; Gorman, D. M.; Pflanz, S (2011). "C17 prevents inflammatory arthritis and associated joint destruction in mice". PLoS ONE. 6 (7): e22256. doi:10.1371/journal.pone.0022256. PMC 3143151. PMID 21799806.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Chen, X. D.; Xiong, D. H.; Yang, T. L.; Pei, Y. F.; Guo, Y. F.; Li, J; Yang, F; Pan, F; Tan, L. J.; Yan, H; Liu, X. G.; Lei, S. F.; Li, X; Ning, L. L.; Zhu, X. Z.; Levy, S; Kranzler, H. R.; Farrer, L. A.; Gelernter, J; Recker, R. R.; Deng, H. W. (2012). "ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior". Chinese medical journal. 125 (6): 1127–34. PMID 22613542.
Liu, X; Rapp, N; Deans, R; Cheng, L (2000). "Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells". Genomics. 65 (3): 283–92. doi:10.1006/geno.2000.6170. PMID 10857752.
Kwon, Y. J.; Lee, S. J.; Koh, J. S.; Kim, S. H.; Lee, H. W.; Kang, M. C.; Bae, J. B.; Kim, Y. J.; Park, J. H. (2012). "Genome-wide analysis of DNA methylation and the gene expression change in lung cancer". Journal of Thoracic Oncology. 7 (1): 20–33. doi:10.1097/JTO.0b013e3182307f62. PMID 22011669.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170891 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062329 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Cytokine-like 1". Retrieved 2014-02-01.

[6] Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation" PLoS ONE 11(1): e0147424. doi:10.1371/journal.pone.0147424

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Function

References

Further reading