Calmegin

CLGN
Identifiers
Aliases	CLGN, calmegin
External IDs	OMIM: 601858; MGI: 107472; HomoloGene: 68392; GeneCards: CLGN; OMA:CLGN - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	140,427,661 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,155,181 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium of left ventricle; ; left testis; ; right testis; ; cardiac muscle tissue of right atrium; ; right auricle; ; endothelial cell; ; islet of Langerhans; ; apex of heart; ; retinal pigment epithelium;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; olfactory epithelium; ; lumbar spinal ganglion; ; trigeminal ganglion; ; facial motor nucleus; ; anterior horn of spinal cord; ; medulla oblongata; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein folding chaperone activity; calcium ion binding; protein binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; nuclear envelope;
Biological process	protein folding; single fertilization; binding of sperm to zona pellucida; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	1047
	12745
	ENSG00000153132
	ENSMUSG00000002190
	O14967
	P52194
	NM_001130675; NM_004362
	NM_009904; NM_001329627; NM_001329680
	NP_001124147; NP_004353
	NP_001316556; NP_001316609; NP_034034
	Wikidata
View/Edit Human	View/Edit Mouse

Calmegin, also known as CLGN, is a protein which in humans is encoded by the CLGN gene.^[5] Calmegin is also present in other animals including mice.^[6]

Function

Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153132 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002190 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CLGN calmegin".
^ Watanabe D, Yamada K, Nishina Y, Tajima Y, Koshimizu U, Nagata A, Nishimune Y (March 1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development". J. Biol. Chem. 269 (10): 7744–9. PMID 8126001.

Function

References

Further reading