Hepacivirus A
| Hepacivirus A | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Kitrinoviricota |
| Class: | Flasuviricetes |
| Order: | Amarillovirales |
| Family: | Flaviviridae |
| Genus: | Hepacivirus |
| Species: | Hepacivirus A
|
| Synonyms[1] | |
| |
Hepacivirus A, or Canine hepacivirus (CHV) or Equine hepacivirus (EHV), is a positive-sense single-stranded RNA virus of the genus Hepacivirus.[2] It infects dogs and horses, and causes pulmonary infections in dogs. Unlike the related Hepatitis C virus, it is not known to cause hepatitis in either host.
History
[edit]The virus was isolated in 2011 from a number of dogs suffering from respiratory infections. Later, distinct lineages were isolated from horses in different locations.[citation needed]
Genome
[edit]As of 2012, the genome has not yet been fully sequenced. The available sequence is about 6,500 nucleotides in length. It is predicted to have a polyprotein that can be cleaved into 10 smaller proteins. There is a 'slippery sequence' – A5NNA5 – within the genome which may encode a programmed frameshift. It encodes two envelope proteins (E1 and E2) as well as cysteine and serine proteases.[citation needed]
The overall G+C content is 50.7%.[citation needed]
Evolution
[edit]The virus appears to have evolved from the Hepatitis C virus between 500 and 1,000 years ago.[citation needed]
The equine lineages (EHV) are more diverse than the canine lineages (CHV), suggesting that the former are ancestral to the latter. CHV appears to have originated in a cross-species transmission from horses to dogs around 1970. The origin of EHV is not known, but it seems that both EHV and Hepatitis C virus have originated in separate cross-species transmission events from a common source.[3]
References
[edit]- ^ Smith, Donald B.; et al. (23 June 2016). "Create 13 new species in the genus Hepacivirus and rename 1 species (family Flaviviridae)" (PDF). International Committee on Taxonomy of Viruses (ICTV). p. 3. Retrieved 13 March 2019.
All other species are named according to the date of publication of a complete coding sequence with the exception of Hepacivirus B which includes GBV-B (providing a memorable link) and Hepacivirus A (canine hepacivirus/non-primate hepacivirus).
- ^ Kapoor A, Simmonds P, Gerold G, Qaisar N, Jain K, Henriquez JA, Firth C, Hirschberg DL, Rice CM, Shields S, Lipkin WI (2011). "Characterization of a canine homolog of hepatitis C virus". Proc. Natl. Acad. Sci. U.S.A. 108 (28): 11608–13. Bibcode:2011PNAS..10811608K. doi:10.1073/pnas.1101794108. PMC 3136326. PMID 21610165.
- ^ Pybus, Oliver G; Thézé, Julien. "Hepacivirus cross-species transmission and the origins of the hepatitis C virus" (PDF). evolve.zoo.ox.ac.uk. Archived from the original (PDF) on 2021-12-05. Retrieved December 5, 2021.