Capping protein (actin filament) muscle Z-line, alpha 1

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CAPZA1
Protein CAPZA1 PDB 1izn.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CAPZA1, CAPPA1, CAPZ, CAZ1, capping actin protein of muscle Z-line alpha subunit 1
External IDs MGI: 106227 HomoloGene: 24376 GeneCards: CAPZA1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006135

NM_009797

RefSeq (protein)

NP_006126

NP_033927.2
NP_033927

Location (UCSC) Chr 1: 112.62 – 112.67 Mb Chr 3: 104.82 – 104.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.[3][4][5]

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein.

Function[edit]

The protein regulates growth of the actin filament by capping the barbed end (plus-end) of growing actin filaments, preventing any further assembly from occurring.[5] This protein can be bound to the lipid PIP2 preventing it from binding to actin filaments.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Barron-Casella EA, Torres MA, Scherer SW, Heng HH, Tsui LC, Casella JF (Oct 1995). "Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families". J Biol Chem. 270 (37): 21472–9. doi:10.1074/jbc.270.37.21472. PMID 7665558. 
  4. ^ Hart MC, Korshunova YO, Cooper JA (Apr 1997). "Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes". Genomics. 39 (3): 264–70. doi:10.1006/geno.1996.4506. PMID 9119363. 
  5. ^ a b "Entrez Gene: CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1". 

Further reading[edit]