Cdc42 effector protein 5

CDC42EP5
Identifiers
Aliases	CDC42EP5, Borg3, CEP5, CDC42 effector protein 5
External IDs	OMIM: 609171; MGI: 1929745; HomoloGene: 10984; GeneCards: CDC42EP5; OMA:CDC42EP5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,473,296 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,167,859 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; olfactory zone of nasal mucosa; ; prostate; ; rectum; ; ascending aorta; ; tibial nerve; ; Descending thoracic aorta; ; canal of the cervix; ; Achilles tendon;
	Top expressed in
	intestinal villus; ; duodenum; ; transitional epithelium of urinary bladder; ; epithelium of stomach; ; mucous cell of stomach; ; large intestine; ; pyloric antrum; ; colon; ; crypt of lieberkuhn of small intestine; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity;
Cellular component	cytosol; cytoskeleton; endomembrane system; membrane; plasma membrane; cytoplasm;
Biological process	JNK cascade; positive regulation of pseudopodium assembly; positive regulation of actin filament polymerization; regulation of cell shape; positive regulation of GTPase activity; Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	148170
	58804
	ENSG00000167617
	ENSMUSG00000063838
	Q6NZY7
	Q9Z0X0
	NM_145057
	NM_021454
	NP_659494
	NP_067429
	Wikidata
View/Edit Human	View/Edit Mouse

CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. ^[5]

Function

Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167617 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063838 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CDC42 effector protein 5". Retrieved 2018-04-25.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167617 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CDC42 effector protein 5". Retrieved 2018-04-25.

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