Cholesterol-5,6-oxide hydrolase
| Cholesterol-5,6-oxide hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.3.2.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cholesterol-5,6-oxide hydrolase (EC 3.3.2.11, cholesterol-epoxide hydrolase, ChEH) is an enzyme with systematic name 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O 5alpha-cholestane-3beta,5alpha,6beta-triol
- (2) 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O 5alpha-cholestane-3beta,5alpha,6beta-triol
The enzyme works equally well with either epoxide as substrate.
References
- ^ Levin, W.; Michaud, D.P.; Thomas, P.E.; Jerina, D.M. (1983). "Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6 α-oxide and certain xenobiotic alkene and arene oxides". Arch. Biochem. Biophys. 220: 485–494. doi:10.1016/0003-9861(83)90439-3. PMID 6401984.
- ^ Oesch, F.; Timms, C.W.; Walker, C.H.; Guenthner, T.M.; Sparrow, A.; Watabe, T.; Wolf, C.R. (1984). "Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities". Carcinogenesis. 5: 7–9. doi:10.1093/carcin/5.1.7. PMID 6690087.
- ^ Sevanian, A.; McLeod, L.L. (1986). "Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase". J. Biol. Chem. 261: 54–59. PMID 3941086.
- ^ Fretland, A.J.; Omiecinski, C.J. (2000). "Epoxide hydrolases: biochemistry and molecular biology". Chem. Biol. Interact. 129: 41–59. doi:10.1016/S0009-2797(00)00197-6. PMID 11154734.
- ^ Newman, J.W.; Morisseau, C.; Hammock, B.D. (2005). "Epoxide hydrolases: their roles and interactions with lipid metabolism". Prog. Lipid Res. 44: 1–51. doi:10.1016/j.plipres.2004.10.001. PMID 15748653.
External links
- +cholesterol-5,6-oxide+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)