Clemens van Blitterswijk

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Clemens van Blitterswijk
VanBlitterswijk.JPG
Clemens van Blitterswijk
Born1957 (age 63–64)
The Hague, Netherlands
NationalityNetherlands
Alma materUniversity of Leiden
AwardsJean Leray Award;

The Marie Parijs Award; The Klein Award;

George Winter Award; Huibregtsen Prize; Career Achievement Award;
Scientific career
FieldsBiomedical engineering, biomaterials, tissue engineering
InstitutionsUniversity of Maastricht

Clemens A. van Blitterswijk (1957, The Hague) is a Dutch scientist in tissue engineering, a field that aims to replace or regenerate diseased or damaged tissues through a combination of material engineering and cell biology. He has contributed to the use of synthetic biomaterials to heal bone injuries, especially to an approach termed osteoinduction that aims at designing biomaterials that trigger the surrounding cells to form new bone tissue in vivo.[1] One example of this contribution to osteoinduction is a paper published in collaboration with Joost de Bruijn and Huipin Yuan.[2] In collaboration with Jan de Boer and others, Blitterswijk has contributed to applying high-throughput screening to study cell-biomaterial interactions on engineered microtextures, an approach termed materiomics.

Career[edit]

Blitterswijk graduated from a bachelor in cell biology at Leiden University. He defended his PhD thesis in 1985 at the same university on artificial ceramic middle ear implants under the supervision of Professor Jan Grote[3] and Klaas de Groot,[4] for which he was awarded the Jean Leray young scientist award from the European Society for Biomaterials in 1987.[5] From 1985 to 1996, he worked on hydroxyapatite biomaterials for middle ear implants under the mentorship of Jan Grote[6][7][8] and Klaas De Groot[9][10] at Leiden University.

In 1996, he left Leiden University and co-founded, together with Klaas De Groot, IsoTis BV the Netherlands, a life sciences company focused on bone biomaterials and tissue engineering.

In 1997, he became a full professor at University of Twente. In 2014, he was appointed director of the University of Twente’s MIRA, Institute for Biomedical Technology and Technical Medicine institute, that no longer exists. At Twente University, in collaboration with Jan de Boer and Hemant Unadkat, and in collaboration with Dimitri Stamatialis, he contributed to the development of a high-throughput assay to design and select in a non-biased manner, micrometer-scale surface textures of biomaterials that enhance specific cellular functions (e.g. bone formation). This resulted in a micro-fabricated platform termed TopoChip.[11][12]

In 2012, in parallel to his positions at Twente University, he became a partner of the Life Science Partner (LSP) private investment firm. His prime focus and responsibility within LSP is to invest in private companies and start ups related to healthcare innovations.[13]

In 2014, he became a distinguished professor at Maastricht University, while maintaining his activities at LSP.[14] Between 2014 and 2018, he acted as the director and department chair at the MERLN Institute for Technology-Inspired Regenerative Medicine at Maastricht University. In 2015, he was awarded an ERC Advanced grant that aimed at developing microfabricated and microfluidic cell culture platforms for improving mouse organoids reflecting the pancreatic islets, the pituitary gland, and the embryo.[15] The conception of this grant application and the research relative to it was done by several principal investigators at the MERLN Institute.[16][17][18][19][20][21] In 2017, he was a member of a consortium led by Carlijn Bouten that received the Gravitation grant of the Dutch Research Council (NWO) to develop materials-driven approaches for tissue regeneration.[22]

In 2017, he became a member of the board of Kuros Biosciences. This company is focused on the development of products for tissue repair and regeneration and is located in Schlieren (Zürich, Switzerland), Bilthoven (The Netherlands) and Burlington (MA, United States). He is currently chairman of the Board of Directors.[23]

He is one of the founders of an international consortium named Regenerative Medicine Crossing Borders; RegMed XB),[24] established in 2018, that aims to bring multiple biomaterial- and cell-based therapies for selected chronic diseases to the clinic in the next ten years. That same year, a publication by one of the principal investigators at the MERLN Institute on the creation of a preimplantation embryo model generated solely from stem cells gained widespread media attention.[25][26][27]

He is a fellow of the International Union of Societies for Biomaterials Science and Engineering.[28] He has been a member of the Netherlands Academy of Technology and Innovation (AcTI)[29] since 2003, the Royal Netherlands Academy of Arts and Sciences (KNAW) since 2012, and the Royal Holland Society of Sciences and Humanities (KHMW) since 2016. He is listed as an associate editor of the Journal of Tissue Engineering and Regenerative Medicine.[30]

Valorization[edit]

He has also contributed to several companies and, from 1996 to 2002, served as CEO of IsoTis, a company specialised in bone graft substitutes.[31] In 2007, IsoTis underwent an Initial Public Offering and was subsequently acquired by Integra LifeSciences.[32][33] He is registered as a contributor to 34 patents.[34] In 2018, he became the chairman of the board of directors of Kuros Biosciences.[23]

He has been named the most entrepreneurial scientist in the Netherlands in 2012[35] and received the Huibregtsen award in 2015.[36]

He is a partner of the Health Economics Funds (HEF) of the European health care investment group Life Sciences Partners[37] (LSP), a healthcare investment firms in Europe. The two HEF funds[38] have raised close to €400 million for technologies that aim at improving the quality of health care while lowering the cost of it, focused specifically on medical devices, diagnostics, and digital health. HEF2 has raised €280 million.[1]

Teaching[edit]

Blitterswijk has been the official supervisor of over 80 PhD candidates who, in their large majority, have worked in the laboratories of other principal investigators at the universities of Twente and Maastricht. He has participated as an editor of four textbooks, including one dedicated to tissue engineering.[39]

Awards[edit]

He has been awarded the following prizes:

  • Jean Leray award in 1989 for the work in his PhD thesis[5]
  • Professor de Kleijn award in 1989 for the work in his PhD thesis
  • George Winter senior scientist award in 1997[40]
  • Federa award in 2012[41]
  • "Most entrepreneurial scientist" award in 2012[35]
  • Career Achievement award of the EU Chapter of the Tissue Engineering and Regenerative Medicine International Society in 2013[42]
  • Huibregtsen award in 2015.[36]

Ten major publications[edit]

  • Levenberg S, Rouwkema J, Macdonald M, Garfein ES, Kohane DS, Darland DC, Marini R, van Blitterswijk CA, Mulligan RC, D'Amore PA, Langer R (July 2005). "Engineering vascularized skeletal muscle tissue". Nature Biotechnology. 23 (7): 879–84. doi:10.1038/nbt1109. PMID 15965465. S2CID 28136064.
  • Moroni L, de Wijn JR, van Blitterswijk CA (March 2006). "3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties". Biomaterials. 27 (7): 974–85. doi:10.1016/j.biomaterials.2005.07.023. PMID 16055183.
  • Rouwkema J, de Boer J, Van Blitterswijk CA (September 2006). "Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct". Tissue Engineering. 12 (9): 2685–93. doi:10.1089/ten.2006.12.2685. PMID 16995802.
  • Meijer GJ, de Bruijn JD, Koole R, van Blitterswijk CA (February 2007). "Cell-based bone tissue engineering". PLOS Medicine. 4 (2): e9. doi:10.1371/journal.pmed.0040009. PMC 1800310. PMID 17311467.
  • Jukes JM, Both SK, Leusink A, Sterk LM, van Blitterswijk CA, de Boer J (May 2008). "Endochondral bone tissue engineering using embryonic stem cells". Proceedings of the National Academy of Sciences of the United States of America. 105 (19): 6840–5. doi:10.1073/pnas.0711662105. PMC 2374550. PMID 18467492.
  • Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AM, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD (August 2010). "Osteoinductive ceramics as a synthetic alternative to autologous bone grafting". Proceedings of the National Academy of Sciences of the United States of America. 107 (31): 13614–9. doi:10.1073/pnas.1003600107. PMC 2922269. PMID 20643969.
  • Unadkat HV, Hulsman M, Cornelissen K, Papenburg BJ, Truckenmüller RK, Carpenter AE, Wessling M, Post GF, Uetz M, Reinders MJ, Stamatialis D, van Blitterswijk CA, de Boer J (October 2011). "An algorithm-based topographical biomaterials library to instruct cell fate". Proceedings of the National Academy of Sciences of the United States of America. 108 (40): 16565–70. doi:10.1073/pnas.1109861108. PMC 3189082. PMID 21949368.
  • Rivron NC, Vrij EJ, Rouwkema J, Le Gac S, van den Berg A, Truckenmüller RK, van Blitterswijk CA (May 2012). "Tissue deformation spatially modulates VEGF signaling and angiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 109 (18): 6886–91. doi:10.1073/pnas.1201626109. PMC 3344996. PMID 22511716.
  • Danoux C, Sun L, Koçer G, Birgani ZT, Barata D, Barralet J, van Blitterswijk C, Truckenmüller R, Habibovic P (March 2016). "Development of Highly Functional Biomaterials by Decoupling and Recombining Material Properties". Advanced Materials. 28 (9): 1803–8. doi:10.1002/adma.201504589. PMID 26689847.
  • Rivron NC, Frias-Aldeguer J, Vrij EJ, Boisset JC, Korving J, Vivié J, Truckenmüller RK, van Oudenaarden A, van Blitterswijk CA, Geijsen N (May 2018). "Blastocyst-like structures generated solely from stem cells". Nature. 557 (7703): 106–11. doi:10.1038/s41586-018-0051-0. PMID 29720634. S2CID 13749109.

References[edit]

  1. ^ Miron, R.J.; Zhang, Y.F. (August 2012). "Osteoinduction: A Review of Old Concepts with New Standards". Journal of Dental Research. 91 (8): 736–744. doi:10.1177/0022034511435260. ISSN 0022-0345. PMID 22318372.
  2. ^ Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AM, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD (August 2010). "Osteoinductive ceramics as a synthetic alternative to autologous bone grafting". Proceedings of the National Academy of Sciences of the United States of America. 107 (31): 13614–9. doi:10.1073/pnas.1003600107. PMC 2922269. PMID 20643969.
  3. ^ Van Blitterswijk, C. A.; Kuijpers, W.; Daems, W Th; Grote, J. J. (January 1986). "Epithelial Reactions to Hydroxyapatite: An in Vivo and in Vitro Study". Acta Oto-Laryngologica. 101 (3–4): 231–241. doi:10.3109/00016488609132832. ISSN 0001-6489. PMID 3705952.
  4. ^ van Blitterswijk, C.A.; Grote, J.J.; Kuijpers, W.; Daems, W.Th.; de Groot, K. (March 1986). "Macropore tissue ingrowth: a quantitative and qualitative study on hydroxyapatite ceramic". Biomaterials. 7 (2): 137–143. doi:10.1016/0142-9612(86)90071-2. ISSN 0142-9612. PMID 3011138.
  5. ^ a b "ESB European Society for Biomaterials". www.esbiomaterials.eu. Retrieved 1 June 2020.
  6. ^ Nell, M.J.; Op’t Hof, B.M.; Koerten, H.K.; Grote, J.J. (1999). "Effect of Endotoxin on Cultured Human Middle Ear Epithelium". ORL. 61 (4): 201–205. doi:10.1159/000027671. ISSN 0301-1569. PMID 10450054. S2CID 20788406.
  7. ^ Bakker, D.; van Blitterswijk, C. A.; Hesseling, S. C.; Th. Daems, W.; Kuijpers, W.; Grote, J. J. (June 1990). "The behavior of alloplastic tympanic membranes inStaphylococcus aureus-induced middle ear infection. I. Quantitative biocompatibility evaluation". Journal of Biomedical Materials Research. 24 (6): 669–688. doi:10.1002/jbm.820240604. ISSN 0021-9304. PMID 2163404.
  8. ^ Jj, Grote; D, Bakker; Sc, Hesseling; Ca, van Blitterswijk (September 1991). "New Alloplastic Tympanic Membrane Material". The American Journal of Otology. 12 (5): 329–35. PMID 1665011.
  9. ^ van Blitterswijk, C. A.; Hesseling, S. C.; Grote, J. J.; Koerten, H. K.; de Groot, K. (April 1990). "The biocompatibility of hydroxyapatite ceramic: A study of retrieved human middle ear implants". Journal of Biomedical Materials Research. 24 (4): 433–453. doi:10.1002/jbm.820240403. ISSN 0021-9304. PMID 2161412.
  10. ^ Verheyen, C. C. P. M.; De Wijn, J. R.; Van Blitterswijk, C. A.; De Groot, K. (October 1992). "Evaluation of hydroxylapatite/poly(l-lactide) composites: Mechanical behavior". Journal of Biomedical Materials Research. 26 (10): 1277–1296. doi:10.1002/jbm.820261003. ISSN 0021-9304. PMID 1331112.
  11. ^ Unadkat HV, Hulsman M, Cornelissen K, Papenburg BJ, Truckenmüller RK, Carpenter AE, Wessling M, Post GF, Uetz M, Reinders MJ, Stamatialis D, van Blitterswijk CA, de Boer J (October 2011). "An algorithm-based topographical biomaterials library to instruct cell fate". Proceedings of the National Academy of Sciences of the United States of America. 108 (40): 16565–70. doi:10.1073/pnas.1109861108. PMC 3189082. PMID 21949368.
  12. ^ Baker M (November 2011). "Trying out topographies". Nature Methods. 8 (11): 900. doi:10.1038/nmeth.1760. PMID 22167818. S2CID 5421979.
  13. ^ "LSP van Blitterswijk".
  14. ^ "Distinguished university professors – Research – Maastricht University". maastrichtuniversity.nl. Retrieved 1 February 2018.
  15. ^ "Press release Maastricht University". Maastricht University. 8 April 2016.
  16. ^ Geuens, Thomas; van Blitterswijk, Clemens A.; LaPointe, Vanessa L. S. (30 April 2020). "Overcoming kidney organoid challenges for regenerative medicine". NPJ Regenerative Medicine. 5 (1): 8. doi:10.1038/s41536-020-0093-4. ISSN 2057-3995. PMC 7192889. PMID 32377381.
  17. ^ Samal, Pinak; Maurer, Philipp; Blitterswijk, Clemens; Truckenmüller, Roman; Giselbrecht, Stefan (29 April 2020). "A New Microengineered Platform for 4D Tracking of Single Cells in a Stem‐Cell‐Based In Vitro Morphogenesis Model". Advanced Materials. 32 (24): 1907966. doi:10.1002/adma.201907966. ISSN 0935-9648. PMID 32346909.
  18. ^ Kuhnt, Tobias; Marroquín García, Ramiro; Camarero-Espinosa, Sandra; Dias, Aylvin; ten Cate, A. Tessa; van Blitterswijk, Clemens A.; Moroni, Lorenzo; Baker, Matthew B. (2019). "Poly(caprolactone- co -trimethylenecarbonate) urethane acrylate resins for digital light processing of bioresorbable tissue engineering implants". Biomaterials Science. 7 (12): 4984–4989. doi:10.1039/C9BM01042D. ISSN 2047-4830. PMID 31667486.
  19. ^ Sthijns, Mireille M.J.P.E.; LaPointe, Vanessa L.S.; van Blitterswijk, Clemens A. (1 October 2019). "Building Complex Life Through Self-Organization". Tissue Engineering Part A. 25 (19–20): 1341–1346. doi:10.1089/ten.tea.2019.0208. ISSN 1937-3341. PMC 6784492. PMID 31411111.
  20. ^ Rademakers, Timo; Horvath, Judith M.; Blitterswijk, Clemens A.; LaPointe, Vanessa L.S. (October 2019). "Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization". Journal of Tissue Engineering and Regenerative Medicine. 13 (10): 1815–1829. doi:10.1002/term.2932. ISSN 1932-6254. PMC 6852121. PMID 31310055.
  21. ^ "ThiolEne Alginate Hydrogels as Versatile Bioinks for Bioprinting". doi:10.1021/acs.biomac.8b00696.s001. Cite journal requires |journal= (help)
  22. ^ "NWO Gravitation grant results".
  23. ^ a b "Professor Clemens van Blitterswijk". Kuros Biosciences. Retrieved 24 May 2020.
  24. ^ "Home – RegMed XB – Regenerative medicine crossing borders". regmedxb.com.
  25. ^ Rivron, Nicolas C.; Frias-Aldeguer, Javier; Vrij, Erik J.; Boisset, Jean-Charles; Korving, Jeroen; Vivié, Judith; Truckenmüller, Roman K.; van Oudenaarden, Alexander; van Blitterswijk, Clemens A.; Geijsen, Niels (May 2018). "Blastocyst-like structures generated solely from stem cells". Nature. 557 (7703): 106–111. doi:10.1038/s41586-018-0051-0. ISSN 1476-4687. PMID 29720634. S2CID 13749109.
  26. ^ "Scientists build 'synthetic embryos'". BBC News. 3 May 2018. Retrieved 25 October 2020.
  27. ^ Susan Scutti. "Artificial embryo created using only stem cells". CNN. Retrieved 25 October 2020.
  28. ^ nnadilim. "HOME".
  29. ^ https://www.acti-nl.org/en/homepage?set_language=en since
  30. ^ "Journal of Tissue Engineering and Regenerative Medicine – Wiley Online Library". Journal of Tissue Engineering and Regenerative Medicine. doi:10.1002/(issn)1932-7005.
  31. ^ "IsoTis Orthobiologics Archives". SeaSpine.
  32. ^ "IsoTis – Integra Merger". Retrieved 30 September 2018.
  33. ^ "UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934". Retrieved 30 September 2018.
  34. ^ "Google Patents". patents.google.com. Retrieved 24 May 2020.
  35. ^ a b "News_van Blitterswijk most entrepreneurial scientist in 2012". Retrieved 1 February 2018.
  36. ^ a b "Over de prijs". avondwenm.nl.
  37. ^ "HOME". lspvc.com.
  38. ^ "FUNDS >> Private Franchise". lspvc.com.
  39. ^ https://www.amazon.com/dp/0123708699
  40. ^ "ESB European Society for Biomaterials". esbiomaterials.eu.
  41. ^ "Federaprijs-winnaars – Federa". federa.org.
  42. ^ "Archived copy". Archived from the original on 7 July 2017. Retrieved 1 February 2018.CS1 maint: archived copy as title (link)

External links[edit]