Cyclin T2

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CCNT2
Protein CCNT2 PDB 2ivx.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CCNT2, CYCT2, cyclin T2
External IDs MGI: 1920199 HomoloGene: 14043 GeneCards: CCNT2
RNA expression pattern
PBB GE CCNT2 214638 s at fs.png

PBB GE CCNT2 204645 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001241
NM_058241
NM_001320748
NM_001320749

NM_028399

RefSeq (protein)

NP_001232
NP_001307677
NP_001307678
NP_490595

NP_082675.1
NP_082675

Location (UCSC) Chr 2: 134.92 – 134.96 Mb Chr 1: 127.77 – 127.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-T2 is a protein that in humans is encoded by the CCNT2 gene.[3][4][5]

Function[edit]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described.[5]

Interactions[edit]

Cyclin T2 has been shown to interact with CDK9[3] and Retinoblastoma protein.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Peng J, Zhu Y, Milton JT, Price DH (Apr 1998). "Identification of multiple cyclin subunits of human P-TEFb". Genes Dev. 12 (5): 755–62. doi:10.1101/gad.12.5.755. PMC 316581Freely accessible. PMID 9499409. 
  4. ^ Napolitano G, Licciardo P, Gallo P, Majello B, Giordano A, Lania L (Nov 1999). "The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity". AIDS. 13 (12): 1453–9. doi:10.1097/00002030-199908200-00003. PMID 10465067. 
  5. ^ a b "Entrez Gene: CCNT2 cyclin T2". 
  6. ^ Simone C, Bagella L, Bellan C, Giordano A (Jun 2002). "Physical interaction between pRb and cdk9/cyclinT2 complex". Oncogene. 21 (26): 4158–65. doi:10.1038/sj.onc.1205511. PMID 12037672. 

Further reading[edit]

External links[edit]