DBC1

BRINP1
Identifiers
Aliases	BRINP1, DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1
External IDs	OMIM: 602865; MGI: 1928478; HomoloGene: 8754; GeneCards: BRINP1; OMA:BRINP1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	119,369,435 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	68,872,634 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; entorhinal cortex; ; primary visual cortex; ; postcentral gyrus; ; superior frontal gyrus; ; Brodmann area 46; ; prefrontal cortex; ; frontal pole; ; buccal mucosa cell;
	Top expressed in
	visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; piriform cortex; ; prefrontal cortex; ; primary motor cortex; ; subdivision of hippocampus; ; dorsal striatum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; soma; dendrite; endoplasmic reticulum;
Biological process	cell cycle; negative regulation of cell cycle; cell death; behavioral fear response; positive regulation of neuron differentiation; negative regulation of neurogenesis; social behavior; cellular response to retinoic acid; negative regulation of mitotic cell cycle; short-term memory; exploration behavior; maternal behavior; vocalization behavior;
	Sources:Amigo / QuickGO
Orthologs
	1620
	56710
	ENSG00000078725
	ENSMUSG00000028351
	O60477
	Q920P3
	NM_014618
	NM_019967
	NP_055433
	NP_064351
	Wikidata
View/Edit Human	View/Edit Mouse

Template:Distinguish2

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.^[5]^[6]^[7]^[8]^[9]

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.^[7]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078725 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028351 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
^ Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
^ ^a ^b "Entrez Gene: DBC1 deleted in bladder cancer 1".
^ Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
^ Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

References

Further reading