DCTN2

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DCTN2
Identifiers
Aliases DCTN2, DCTN50, DYNAMITIN, HEL-S-77, RBP50, dynactin subunit 2
External IDs MGI: 107733 HomoloGene: 4667 GeneCards: DCTN2
RNA expression pattern
PBB GE DCTN2 200932 s at fs.png

PBB GE DCTN2 214384 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001261412
NM_001261413
NM_006400

NM_001190453
NM_001190454
NM_027151

RefSeq (protein)

NP_081427.1
NP_001177382
NP_001177383
NP_081427

Location (UCSC) Chr 12: 57.53 – 57.55 Mb Chr 10: 127.27 – 127.28 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dynactin subunit 2 is a protein that in humans is encoded by the DCTN2 gene.[3][4]

Function[edit]

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.[4]

Interactions[edit]

DCTN2 has been shown to interact with MARCKSL1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB (July 1996). "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis". J. Cell Biol. 132 (4): 617–33. doi:10.1083/jcb.132.4.617. PMC 2199864Freely accessible. PMID 8647893. 
  4. ^ a b "Entrez Gene: DCTN2 dynactin 2 (p50)". 
  5. ^ Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". J. Biol. Chem. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182. 

Further reading[edit]